Báo cáo khoa học: The in vitro effects of CRE-decoy oligonucleotides in combination with conventional chemotherapy in colorectal cancer cell lines potx
Báo cáo khoa học: Structural and biological effects of a b2- or b3-amino acid insertion in a peptide Application to molecular recognition of substance P by the neurokinin-1 receptor ppt
... in blue, oxygens in red, hydrogens in grey. Carbon atoms of Pro are coloured in cyan, those of other amino acids in green. The side chain methyl carbon of b-HAla and the pro R methyl carbon of ... phospho-lipase C (PLC) in CHO cells transfected with the humanNK-1 receptor [24,25]. Modelling and superimposition of the conformers of the different b-anda-amino acidsinserted in position 9 of SP was performed ... done in parallel experiments with control at t ¼ 0foreach peptide. The percentage of degradation was calculatedby comparing the area of the peaks of the intact peptide att ¼ 0andt ¼ 60 min.Binding...
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Báo cáo khoa học: The C-terminal region of the proprotein convertase 1⁄ 3 (PC1⁄ 3) exerts a bimodal regulation of the enzyme activity in vitro pdf
... frugiperda (Sf)9 cellsexpressing the recombinant mPC1 ⁄ 3, the presence of the 87 kDa form in excess of the 66 ⁄ 71 kDa facilitatesisolation of the enzyme and helps in maintaining the enzymatic ... substrate(pERTKR–MCA) in the presence of increasing concentrations from0to10lM of RP-HPLC purified CT-peptide. The control conditioncorresponds to incubation of the enzyme with the substrate in the absence of ... been shown that the cysteine-rich domain of PC5 ⁄ 6A was responsible formembrane tethering, thus insuring cell- surface anchor-ing [37]. In other cases, the CT-peptide contains integ-ral transmembrane...
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Báo cáo khoa học: The CssRS two-component regulatory system controls a general secretion stress response in Bacillus subtilis pdf
... are involved in the correct folding of proteins and ⁄ or the removal of incompletely synthes-ized, damaged or malfolded proteins in the differentcompartments of the cell [1–4]. By studying the ... membrane cell wall interface [6]. Thereafter, theycan pass the cell wall in order to be released into the growth medium. During these post-translocational sta-ges in protein secretion, prominent ... proteins, lipase A of B. subtilis and humaninterleukin-3, show that the intensity of the protein secretion stressresponse only partly reflects the production levels of the respective proteins.Importantly,...
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Báo cáo khoa học: "THE SYNTAX AND SEMANTICS OF USER-DEFINED MODIFIERS IN A TRANSPORTABLE NATURAL LANGUAGE PROCESSOR" pot
... sorts of conceptual relationships that can occur in the "layered" domains of interest [1]. Finally, the macro file contains the meanings of modifiers, roughly in the form in which they ... MODIFIERS The job of the knowledge acquisition module of LDC, called "Prep" in Figure 1, is to' find out about (a) the vocabulary of the new domain and (b) the composition of the ... UTILIZATION OF THE INFORMATION ACQUIRED DURING PREPROCESSING As shown in Figure i, the English-language processor of LDC achieves domain independence by restricting itself to (a) a domain-independent....
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Báo cáo khoa học: The starch-binding capacity of the noncatalytic SBD2 region and the interaction between the N- and C-terminal domains are involved in the modulation of the activity of starch synthase III fromArabidopsis thaliana pdf
... confirmed the results obtained in the pull-down assays, showing that there is a physicalinteraction between the N- and C-terminal domains of SSIII in vitro. Mapping of the CD-binding region in the N-terminal ... D3 domains,respectively, but not the individual starch-binding domains, are involved in the interaction with the catalytic domain. We also determined that the resi-dues W366 and Y394 in the D2 ... D(316–344) and D(495–535) regions, with the catalytic domains, as wellas the full integrity of the starch-binding capacity of the D2 domain, areinvolved in the modulation of starch synthase III activity.Structured...
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Báo cáo khoa học: The pivotal regulator GlnB of Escherichia coli is engaged in subtle and context-dependent control potx
... involved in the regulationvia interactions with the different proteins operating in the cascade, resulting in an integration of the varioussignals. Indeed, UTase appears to monitor the gluta-mine ... activity of the protein at the bottom of the hierarchy depends on the modification state of that protein. The advantage of modulating the activity of a protein by a cascade-type of regulation rather ... the mean of PII* with the average of the corresponding variable (of cultures containing the same IPTG concentration),rather than making a correlation of a measured variableand PII* of individual...
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Báo cáo khoa học:The isolation and characterization of temperature-dependent ricin A chain molecules in Saccharomyces cerevisiae docx
... and the fate of its two subunits,RTA and the cell- binding galactose-specific lectinricin toxin B chain (RTB), are essential to gain furtherinsights into the mechanism of toxin action [1].During ... polypeptide of the heterodimeric toxin ricin, which is produced in the endosperm of the seed of the castor bean plant,Ricinus communis. The study of ricin, in particular itsroute into target cells ... useful to express inducible toxin in the ER of mutant strains of yeast, in a manner akin to its expres-sion in plant cells [18]. Survivors of toxin expressionmay contain defects in genes normally...
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Báo cáo khoa học: The catalytic significance of the proposed active site residues in Plasmodium falciparum histoaspartic protease ppt
... As seen in Fig. 6A, the position of the catalytic Asp214 residue isfixed with the interaction to (a) the e-amine of Lys78and (b) the imidazole ring of His34. Asp214 also inter-acts with a water ... interaction between the main chain oxygen of Ala216 and the e-amine of Lys78. In H34A mutant (Fig. 6B), the interactionbetween the imidazole ring and Asp214 disappearedand the side chain of Asp214 is ... areconsistent with the reported secondary structures of pepsin-like aspartic proteases which are predominatelyb sheet [16].On the basis of the kinetic behavior of the H34Aand S37A mutants and the inability...
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Báo cáo khoa học: The calcium-binding domain of the stress protein SEP53 is required for survival in response to deoxycholic acid-mediated injury pdf
... plated in media containing Geneticin toselect for cell containing vector DNA (as in Fig. 5A,G). After three weeks, the number of cells was determined by fixing cells and staining with dye. Individual ... in vitro. Cellular stress protein responses play a key role in minimizing cell injury and maintaining tissue integrity in response to damaging levels of an environmentalagent. As such, the integrity ... understanding the molecular function of SEP53. We were thereforeinterested in determining whether the SEP53 gene hadany effects on modifying DCA-induced cell stresses.However, prior to examining the...
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Báo cáo khoa học: The isopenicillin N acyltransferases of Aspergillus nidulans and Penicillium chrysogenum differ in their ability to maintain the 40-kDa ab heterodimer in an undissociated form pdf
... establish if the lack of processing and dissociation of the A. nidulans IAT was due to intrinsic characteristics of the protein itself or to the absence of a processingendopeptidase in the host, the ... a1.6-kb XhoI–XbaI probe containing the penDE gene. The absence of introns was confirmed by sequencing clonescontaining fragments covering the intron sites; the 5¢ end of the cDNA fragment was confirmed ... refolded proteins in the inclusion bodies of E. coli [pPBCab]; lane 5, refolded proteins in the inclusion bodies of E. coli [pPT7ab]. Note that after refolding there is partialprocessing of the 40-kDa...
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