Báo cáo khoa học: The enzyme-binding region of human GM2-activator protein pdf

Tài liệu Báo cáo khoa học: The intracellular region of the Notch ligand Jagged-1 gains partial structure upon binding to synthetic membranes docx

... [36]. A role of the cytoplasmic tail of membrane-spanning proteins in protein protein interactions has also been proved, e.g. the case of the association between the N-terminal region of the membrane-bound ... thatmost of the RIP substrates, including Jagged-1, actu-ally fall in the left-hand side of the plot (nativelyunfolded proteins). All the proteins that clearly fall in the right-hand side of the ... smaller and the dispersionslightly larger (r ¼ 0.25) compared to the valuesobtained for the protein alone (Supplementary Fig-ure S1). Most of the expected cross-peaks in the Ha region of the 1H-15N...

Tài liệu Báo cáo khoa học: The crystal structure of human a-amino-b-carboxymuconatee-semialdehyde decarboxylase in complex with 1,3-dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis ppt

... for the last four residues at the C-terminus. The stereochemistry of the model hasbeen assessed using the program procheck [23]. Ninetyper cent of the residues fall in the most favouredregions ... movement of the two protein residues upon ligand binding. The dotted line highlights the hydrogen bond established between the DHAP phosphatemoiety and Trp191 in the ligand-bound form of the enzyme.S. ... the protein portion shown by a ribbonrepresentation refers to hACMSD, as do the amino acid numbers. The alternative conformations of the Trp–Met couple can beobserved; the arrows indicate the...

Báo cáo khoa học: The A domain of ﬁbronectin-binding protein B of Staphylococcus aureus contains a novel ﬁbronectin binding site pdf

... antigenically distinct [10,11]. The A domain of ClfA and FnBPA bind Fg at the C-terminus of the c-chain [7]. The interaction between the A domain of ClfA and the c-chain of Fg has beenstudied in detail. ... residuesP336 and Y338 of ClfA. One of the objectives of thisstudy was to determine the mechanism of Fg bindingby the A domain of FnBPB.Located distal to the A domains of FnBPA andFnBPB are ... which expressed a chimeric protein con-taining the A domain of FnBPB together with region R and the cell wall anchoring region of S. aur-eus ClfA (Fig. 9A). Region R of ClfA has no knownligand-binding...

Báo cáo khoa học: "THE SYNTACTIC REGULARITY OF ENGLISH NOUN PHRASES" pdf

... tradition of our own These are not parsed as a result of the rigid assumptions about the ordering of arguments and modifiers built into the grammar. These need to be relaxed on the basis of some theory ... (modulo the inclusion of coordination and exclusion of formulae and foreign phrases) because they are based entirely on the literal form of the tags in the LOB treebank. The next stage of our ... from the treebank. Of the 10,150 NPs in this sample of the treebank, 17 were rejected because they were incorrectly analysed and either were not, in fact, NPs or else the boundaries of the...

Báo cáo khoa học: "THE COMPUTATIONAL COMPLEXITY OF AVOIDING CONVERSATIONAL IMPLICATURES" pdf

... inform the hearer of the relevant properties of the shirt, assum- ing the hearer has some domain knowledge about T- shirts. However, if the hearer has this domain knowledge, the use of utterance ... If the attribute values and classifications used in the description are members of a taxonomy, then they can be realized at different levels of specificity. For example, the object in the ... the number of members of Target-Components that rule out at least one member of Excluded. The straight- forward full-brevity algorithm will then need to examine the following number of...

Báo cáo khoa học: The crystal structure of human WD40 repeat-containing peptidylprolyl isomerase (PPWD1) pdf

... described in the liter-ature.Further complicating the ﬁeld of Cyp biology is the fact that many of the 17 Cyps annotated in the human genome have not been thoroughly studied in terms of either enzymatic ... Acceleration of the cis–trans isomerization of the peptide results in the collapse of theseresonances into a single set of peaks. (D) Binding, but not isomerization, of the N-terminal peptide of PPWD1. ... site in the cur-rent structure might be a product of an inability of the Fig. 1. Structure of PPWD1 and comparison with other Cyp structures. (A) The structure of the isomerase domain of PPWD1...

Báo cáo khoa học: The phosphorylation pattern of human as1-casein is markedly different from the ruminant species potx

... withj-casein in human milk [12]. The molecular cloning andsequencing of mRNA transcripts revealed the presence of three forms of as1-casein in human milk [13,14]. In the present study, we report the phosphorylation ... indicating the presence of asingle phosphorylation in the peptide. Furthermore, the Fig. 2. Localization of phosphorylations in human as1-casein. The amino acid sequence was deduced from the cDNA ... as1-casein. The region containing the phosphorylated residues, Ser18Fig. 4. MALDI-TOF MS of intact human as1-casein. The peak at m/z20233 corresponds well to the calculated mass of human as1-caseinincluding...

Báo cáo khoa học: A metabolomics perspective of human brain tumours pdf

... informa-tion such as the metabolic activity of the lactate pool, the intracellular location of this pool and the relativerates of glycolysis and oxidative metabolism in thesetumours [49–51].Paediatric ... monitoring of brain tumourmetabolites The use of NMR spectroscopy to proﬁle metabolitesin tumour cells and tissues has been applied to awide range of human tumours for a number of years,with the ... with degree of tumour necrosis and the proportion of PC to choline correlated with the malignancy of the glioma [19]. This had previously been shown by solu-tion state multinuclear MRS of glioma...

Báo cáo khoa học: The inﬂuence of cholesterol on the interaction of HIV gp41 membrane proximal region-derived peptides with lipid bilayers potx

... phase,respectively; cLis the lipidic molar volume [26] and[L] is the concentration of the lipid accessible to the peptide (the outer leaﬂet of the bilayer). In the presence of POPC LUV, for MPRP-C,MPRP-S ... mayreach the point where all of the membrane is homoge-neous. The MPRP-C is insensitive to the cholesterolcontent in the membrane, which is in agreement with the insensitivity of the peptide to the ... destabilizing them [15,16] and the presence of cholesterol and sphingomyelin (majorcomponents of the viral membrane) have an importantrole for the membrane perturbing actions of the pep-tide [17,18].There...

Báo cáo khoa học: "The clinical value of daily routine chest radiographs in a mixed medical–surgical intensive care unit is low"

... intravenouslines). The observers were not involved in the daily care of the patients, and ICU physicians were not aware of this part of the observation. As a consequence, the clinical relevance of the predefined ... for other infections, and the absence of radiological signs of pulmonary congestion mighthave resulted in another fluid therapy regimen.We did not score for the clinical relevance of the unexpectedpresence ... determine the inci-dence of major abnormalities on daily routine CXRs and theirimpact on management of ICU patients.Materials and methodsData on all daily routine CXRs ordered at the ICU of the...

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