Báo cáo khoa học: Alpha-fetoprotein antagonizes X-linked inhibitor of apoptosis protein anticaspase activity and disrupts XIAP–caspase interaction ppt

... AFP antagonizes XIAP functionFEBS Journal 273 (2006) 3837–3849 ª 2006 The Authors Journal compilation ª 2006 FEBS 3849 Alpha-fetoprotein antagonizes X-linked inhibitor of apoptosis protein anticaspase ... Ac-Asp-Glu-Val-Asp-7-amino-4-methyl coumarin; AFP, a-fetoprotein; IAP, inhibitor of apoptosis protein; IBM, IAP-bindingmotif; RFU, relative ﬂuorescence units; XIAP, X-linked inhibitor of apoptosis protein. FEBS Journal 273 ... cellular inhibitor- of- apoptosis proteins (IAPs), bind directly to active caspases and actas natural inhibitors of caspase activity [7]. The IAPfamily, currently identiﬁed in humans consists of X-linked...

Tài liệu Báo cáo khoa học: Rac upregulates tissue inhibitor of metalloproteinase-1 expression by redox-dependent activation of extracellular signal-regulated kinase signaling pptx

... kinase (JNK) and reactive oxygen species (ROS) on Tiam1 ⁄ Rac-induced upregulation of tissue inhibitor of metalloproteinase-1 (TIMP-1). (A) Effects of cat-alase and speciﬁc inhibitors of mitogen-activated ... Seiki M (1994)Tax proteins of human T-cell leukemia virus type 1 and 2 induce expression of the gene encodingerythroid-potentiating activity (tissue inhibitor of metalloproteinases-1, TIMP-1). ... Inhibition of activa-tor protein- 1 binding activity and phosphatidylinositol3-kinase pathway by nobiletin, a polymethoxy ﬂavo-noid, results in augmentation of tissue inhibitor of metalloproteinases-1...

Tài liệu Báo cáo khoa học: Post-translational modiﬁcations of the linker histone variants and their association with cell mechanisms docx

... oftenoverexpressed in solid and wet cancer types [10]. Muta-tions and ampliﬁcation of the androgen receptor gene,without loss of gene expression, play a key role in thedevelopment of advanced, androgen-independent ... Swiss-Prot and similar databases.Structure and function of the linkerhistone variantsLocation and structure of the linker histonesHistorically, the location of the globular domain of thelinker ... sequence,most often occurring in short stretches of CpG-richregions known as CpG islands. Such regions are about0.5–2 kb long and can be found in the 5¢-region of approximately 60% of genes, near...

Tài liệu Báo cáo khoa học: "The grapho-phonological system of written French: Statistical analysis and empirical validation" pdf

... subjects and by items in both the immediate naming and the delayed naming task. By-subjects and by-items (Ft and F2, respectively) analyses of variance were performed with grapheme frequency and ... grapheme detectors as a function of frequency of occurrence and differences in the strength of the connections between graphemes and phonemes as a function of association probability would ... the frequency of graphemic units in the language and by the predictability of their mapping to phonemes. We argue that these results implicate the availability of graded knowledge of grapheme-phoneme...

Báo cáo khoa học: PRDM1/Blimp1 downregulates expression of germinal center genes LMO2 and HGAL pot

... upstream promoters of both HGAL and LMO2. PRDM1binding suppresses endogenous protein and mRNA levels of HGAL and LMO2. In addition, promoter analysis reveals that site-specific binding of PRDM1 to the ... promoters is capable of repressing transcriptional activity. This inhibitory effect of PRDM1 suggests that it has a key role in the loss of HGAL and LMO2 expression upon differentiation of GC B cells ... factor and amplification of RhoAtransforming potential [14].LMO2 gene, located on the short arm of chromosome11 at band 13 (11p13), is a member of the LIM-onlyzinc finger protein family and mediates...

Báo cáo khoa học: Amyloid oligomers: spectroscopic characterization of amyloidogenic protein states docx

... property of amyloidogenic oligomers, atleast in cell culture. Studies of the above-mentionedproteins and of other proteins linked to human amy-loidoses, including lysozyme [11] and prion protein [12], ... characterization of amyloidogenic protein statesMikael Lindgren1 and Per Hammarstro¨m21 Department of Physics, Norwegian University of Science and Technology, Trondheim, Norway2 IFM-Department of Chemistry, ... the structure and properties of proteins has a long history, and techniques for pro-tein-structure characterization cover a very wide range of techniques. As proteins in native and other thermo-dynamically...

Báo cáo khoa học: A new bright green-emitting ﬂuorescent protein – engineered monomeric and dimeric forms pptx

... speed and brightness of DsRedvariants. Protein Eng Des Sel 20, 525–534.23 Verkhusha VV & Lukyanov KA (2004) The molecularproperties and applications of Anthozoa fluorescentproteins and chromoproteins. ... Absorption, fluorescence excitation and emis-sion spectra of VFP and its variants.Fig. S3. pH dependence of the fluorescence of VFP and its variants in comparison with EGFP and Venus.Fig. S4. Representative ... vari-ant of VFP as dVFP.Spectral properties of VFP and its variantsWe proceeded with further characterizations of all fourproteins, namely VFP and its variants mVFP1(N158K), mVFP (T160R) and dVFP...

Báo cáo khoa học: MPP3 is recruited to the MPP5 protein scaffold at the retinal outer limiting membrane ppt

... subcellularlocalization and protein interactions of MPP3. Wedemonstrate the presence of MPP3 at the OLM and its interaction to MPP5. We demonstrate separateMpp3 ⁄ Dlg1 and Mpp4 ⁄ Dlg1 complexes ... lanes 5 and 6) it was visible as a double band of 70 and 80 kDa, due to enrichment of the 80 kDa form [24].The recombinant MPP5 has a molecular weight of 80 kDa. The interaction between MPP3 and ... intermolecular bind-ing of MAGUKs and the clustering of PDZ bindingproteins including DLG1 and PSD95 [39–43]. AsMPP4 has been described to be involved in such an interaction [24], MPP3 and MPP4 might...

Báo cáo khóa học: Differential carbohydrate epitope recognition of globotriaosyl ceramide by verotoxins and a monoclonal antibody pdf

... delay time of 175 nsec and low mass gate at800 Da. The mass spectra were externally calibrated withthe molecular mass of a mixture of standard peptides.ResultsComparison of ligand/Gb3binding ... GSLs, heterogeneity of fatty acid, and to a lesser extent, of sphingoid base, generates aspectrum of lipid isoforms of Gb3. Both the lipid structure[14–17] and the local membrane phospholipid ... whereVT1 and anti-Gb3colocalized. In the majority of samples,the staining of anti-Gb3 and VT1 corresponded. In somecases, however, tubular staining by anti-Gb3was distinctfrom that of VT1 and...

Báo cáo khoa học: "Sequential Labeling with Latent Variables: An Exact Inference Algorithm and Its Efﬁcient Approximation" ppt

... sequence of observations x =x1, x2, . . . , xm and a sequence of labels y =y1, y2, . . . , ym. Each yjis a class label for the j’thtoken of a word sequence, and is a member of aset ... Inference Algorithm and Its Efﬁcient ApproximationXu Sun†Jun’ichi Tsujii†‡§†Department of Computer Science, University of Tokyo, Japan‡School of Computer Science, University of Manchester, ... (averaged number of latent paths beingsearched), and inference time of the DPLVM-LDImodel, against the parameter n, on the develop-ment dataset of the Bio-NER task. (Right) En-largement of the beginning...

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