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Báo cáo khoa học: Structural and thermodynamic insights into the binding mode of five novel inhibitors of lumazine synthase from Mycobacterium tuberculosis pptx

Báo cáo khoa học: Structural and thermodynamic insights into the binding mode of five novel inhibitors of lumazine synthase from Mycobacterium tuberculosis pptx

Báo cáo khoa học: Structural and thermodynamic insights into the binding mode of five novel inhibitors of lumazine synthase from Mycobacterium tuberculosis pptx

... range. The analysis of the struc-tures demonstrated the specific features of the binding of different inhibi-tors. The comparison of the structures and binding modes of five different inhibitors ... for comparison of binding affinities of the inhibitors under study. The fitting of the binding isotherms of all five com-pounds with a binding model assuming identical and independent binding sites ... nitrogen and main and side-chain oxygen atoms of Ala59 and Glu61 of one subunit and with the main chain nitro-gen of Asn114¢ of the other subunit. The contacts of the ribityl chain to His89 and Lys138¢...
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Báo cáo khoa học: Structural and functional insights into Erwinia carotovora L-asparaginase ppt

Báo cáo khoa học: Structural and functional insights into Erwinia carotovora L-asparaginase ppt

... advantages of both EcAII and ErA.To gain further insights into EwA and to assess itssuitability as a drug candidate, we have determined the crystal structure of the enzyme in the presence of Asp and ... any of the eight individual monomers, due to the lack of sufficient electron density. The Ramachandranplot showed 89.2% of the non-Gly and non-Pro resi-dues in the most preferable region and ... disulfide bond into EwA may alter the properties of the enzyme and improve its stability.Active site The catalytic site of the enzyme is located between the N-terminal and C-terminal domains of adjacent...
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Tài liệu Báo cáo khoa học: Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1 docx

Tài liệu Báo cáo khoa học: Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1 docx

... atoms,whereas the side chain of Lys173 interacts with bothO6 and N7 (Fig. 1C). The 2¢OH of the ribose is hydro-gen bonded to the main chain and the side chain of Asp142 (Fig. 1C). Both hydroxyl groups of ... hypoxanthine and guanine is only 0.26% and 0.09%, respectively, of the activity of HPRT, the role of the PRTFDC1 in purine metabolism remainsunclear and it is uncertain whether it has the capacityto ... role, although the molecular basis for this activity remains to be eluci-dated. The elucidation of the structure of PRTFDC1 and the definition of its ligand binding specificity from a large metabolome...
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Tài liệu Báo cáo khoa học: Structural and mechanistic aspects of flavoproteins: electron transfer through the nitric oxide synthase flavoprotein domain pdf

Tài liệu Báo cáo khoa học: Structural and mechanistic aspects of flavoproteins: electron transfer through the nitric oxide synthase flavoprotein domain pdf

... interaction between the FMN subdomain and the FNR subdomain, although some may alsoinfluence the rate of electron import into the FMN sub-domain and the resulting formation of FMNH2. The extent to ... hinge domains The composition of the two hinges that connect the FMN subdomain in NOS enzymes (H1 and H2 inFig. 5) defines the allowable movements of the FMNsubdomain and thus controls the FMN–NOSoxy ... Munro AW & ScruttonNS (2004) Thermodynamic and kinetic analysis of the isolated FAD domain of rat neuronal nitric oxide synthase altered in the region of the FAD shieldingresidue Phe1395....
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Tài liệu Báo cáo khoa học: Structural and mechanistic aspects of flavoproteins: probes of hydrogen tunnelling pptx

Tài liệu Báo cáo khoa học: Structural and mechanistic aspects of flavoproteins: probes of hydrogen tunnelling pptx

... Klinman and cowork-ers to study the viscosity dependence of the rate of hydride transfer in GO [70,71]. These authors studiedvarious glycoforms of the enzyme (varying in the extent of glycosylation) ... Stopped-flow traces of the observed FMN reduction during the reaction of the wild-type (wt) and N189A mutant of MR withNADH. The wt trace is fit to a single exponential and the N189Atrace to ... tem-perature dependence of a-2° KIEs during the RHR inMR and PETNR [18,40], and for hydride transfer in the thermophilic dihydrofolate reductase (DHFR) from Thermotoga maritima [43]. The equilibrium...
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Tài liệu Báo cáo khoa học: Structural and mechanistic aspects of flavoproteins: photosynthetic electron transfer from photosystem I to NADP+ doc

Tài liệu Báo cáo khoa học: Structural and mechanistic aspects of flavoproteins: photosynthetic electron transfer from photosystem I to NADP+ doc

... orientation of the N5 of the flavin, the hydride to be transferred, and C4 of the nicotinamide. In FNR, displacement of the C-terminal Tyr appears to be required for the interaction to occur [117,118]. The ... because the semiquinone H-bond with the CO of Asn is weaker than the bond formed with the sma-ller Gly, and because of the presence in the oxidizedstate of a N(5)–HN59 H-bond that is absent in otherFlds. ... protonation – the N5 position.Electron transfer from PSI toflavodoxinFd and Fld differ in size and in the chemical nature of their redox cofactors. There is no sequence homologybetween them, but structural...
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Tài liệu Báo cáo khoa học: Structural and functional studies on a mesophilic stationary phase survival protein (Sur E) from Salmonella typhimurium ppt

Tài liệu Báo cáo khoa học: Structural and functional studies on a mesophilic stationary phase survival protein (Sur E) from Salmonella typhimurium ppt

... indicate the starting and ending residues of the secondary structural elements. (C) The domain-swapped dimer of St SurE. The A and B subunits areshown in green and blue, respectively. The darker and ... change from a ‘closed’ to an‘open’ form. The shift in the position of the loop away from the metal ion leads to the formation of two inter-protomer active sites where the Oe of E37 from onesubunit ... as in archaic and thermophilic homo-logues. The St SurE monomer consists of 13 b-strands,six a-helices and three 310-helices. The core of the pro-tein is made up of a nine-stranded b-sheet...
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Tài liệu Báo cáo khoa học: Structural and functional investigations of Ureaplasma parvum UMP kinase – a potential antibacterial drug target ppt

Tài liệu Báo cáo khoa học: Structural and functional investigations of Ureaplasma parvum UMP kinase – a potential antibacterial drug target ppt

... bonds,one from 2¢-OH to the side chain of Asp70, and one from the backbone N of Gly63, and the phosphategroup forming hydrogen bonds from O1 to Arg55, from O2 to the backbone N and the side chain of Thr138, ... E. coli. The probable binding motif for the uracil base is through hydrogen bonds from N3 to the backbone O of Phe133, and from O4to the backbone N and the side chain of Thr131, with the ribose ... and D + F, and (c) electrostatic forces in the central channel of the hexamer between B, C and F, and A, D and E. The hydrophobic interactionsbetween A and B (Fig. 3A,B) are formed between the antiparallel...
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Tài liệu Báo cáo khoa học: Structural and biochemical characterization of a human adenovirus 2/12 penton base chimera pptx

Tài liệu Báo cáo khoa học: Structural and biochemical characterization of a human adenovirus 2/12 penton base chimera pptx

... the Kdfor the initial bind-ing of minifiber. The fluorescence emission of the TMRwas assumed to be independent of the binding of the minifiber to the penton base, because it is attached at the ... investigate the possibility of couplingbetween the conformation of the hypervariable loop,which contains the integrin -binding site, and the fiber- binding site of the penton base. Based on the fluores-cence ... is the measured anisotropy value, AFis the aniso-tropy of the free minifiber, ABis the anisotropy of the mini-fiber bound to the penton base, [LigB] is the concentration of the bound ligand...
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Tài liệu Báo cáo khoa học: Structural and functional specificities of PDGF-C and PDGF-D, the novel members of the platelet-derived growth factors family docx

Tài liệu Báo cáo khoa học: Structural and functional specificities of PDGF-C and PDGF-D, the novel members of the platelet-derived growth factors family docx

... lymphoid cell infiltrates of the lung and fibro-sis in the liver [110].Conclusions The novel members, PDGF-C and -D, of the PDGFsubfamily of the cystine knot family of growth factorsare potent ... removal of the CUBdomains and thereby activation of the growth factordomains. PDGF-C and -D contain both the CUB and growth factor domains when they are secreted and pro-teolytic cleavage is therefore ... model of the PDGF-C growth factor domain indicates the disulfidebridges in PDGF-C to consist of Cys250 and 294,Cys280 and 335, and Cys287 and 337, and the inter-monomeric bonds to consist of...
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