... that the RPEL domain of MRTF-A bindsactin more strongly than the RPEL domain of myocar-din, and that the RPEL motif itself is an actin-bindingelement. RPEL1 and RPEL2 of myocardin bind actinweakly ... asSTARS-interacting proteins. These novel proteins con-tain four LIM domains and a C-terminal villin head-piece domain, which mediates actin-binding in severalproteins, such as villin and dematin ... cell lines [94].Table 1. Role of nuclear actin-binding proteins interacting with the androgen receptor. AR, androgen receptor; LBD, ligand-binding domain.Actin-bindingproteinTargetingsequence...