Báo cáo khoa học: Prediction of missing enzyme genes in a bacterial metabolic network Reconstruction of the lysine-degradation pathway ofPseudomonas aeruginosa doc
... missing enzyme genes in a bacterial
metabolic network
Reconstruction of the lysine-degradation pathway of Pseudomonas
aeruginosa
Yoshihiro Yamanishi
1
, Hisaaki Mihara
2
, Motoharu Osaki
2
, Hisashi ... eukaryotes and archaea, and there
is also variation within bacteria. We also focused on
the lysine-degradation pathway because the substrates
and intermed...
... hypotheses that are consistent with the
data and achieve this in a value-free manner. Much of classical biochemis-
try and signalling pathway analysis has concentrated on the analyses of
changes in the ... visualiz-
ing, and integrating molecular pathway data. J Biomed
Inform 37, 43–53.
306 Hoffmann R, Krallinger M, Andres E, Tamames J,
Blaschke C & Valencia A (2005)...
... Since ad-hoc manual translation can
represent a significant investment in time and
money, a prior assesment of the amount of
training data required to achieve a satisfac-
tory accuracy level can ... Linguistics
Prediction of Learning Curves in Machine Translation
Prasanth Kolachina
∗
Nicola Cancedda
†
Marc Dymetman
†
Sriram Venkatapathy
†
∗ LTRC, IIIT-Hyderabad, Hyderabad,...
... referenced argument of a
j
, 5) a
i
ACa
j
: a
j
is
the continuation argument of a
i
, 6) a
i
CAa
j
: a
i
is
the continuation argument of a
j
, 7) a
i
= a
j
: a
i
and a
j
are labeled as the same role label, ... automatic parsing data.
2 Prediction of Thematic Rank
2.1 Ranking Arguments in PropBank
There are two main problems in modeling the-
matic hi...
... groups and testing against the
remaining group and a false data set. The false data sets
were created by dividing the remaining sequences in the
ASTRAL data set (4701 sequences) into six equally ... mem-
brane-attached. The transmembrane (TM) helix can be
found in either the N-terminal part of the protein, as in
11-beta hydroxysteroid dehydrogenase type 1 [11], or
in...
... catalyzed by ACC – the key reg-
ulatory enzyme in the pathway. Malonyl-CoA serves as
the basic chain-elongating substrate for the formation
of long-chain saturated fatty acids catalyzed by FAS.
It ... in various organ systems. Even in organisms
lacking a brain, such as Caenorhabditis elegans, the
nervous system plays a key role in maintaining energy
balance [1–4]....
... an
unexpected decrease in PMP-BSA binding. It thus
appears that tethering of the C-terminal end of the
ectodomain is important for both IGF-II and PMP-
BSA binding.
In summary, the major findings ... shown as
rectangles. The shaded rectangles indicate repeats 3 and 9, to
which the main determinants of Man-6-P binding have been
mapped. The stippled rectangles represent rep...
... riboflavin biosynthetic pathway in plants is similar
to that of eubacteria, rather than that in fungi and
archaea. In view of the close similarity between puta-
tive plant deaminases and their apparently ... putative plant pyrimidine reductase
domains catalyse the equivalent reduction to RibD
proteins. In these proteins, the associated deaminase
domains lack an invariant zi...
... fragment
was treated with cisplatin in the same way, the inten-
sity of the R
53
band on the autoradiogram increased
with the degree of DNA modification. The increase
was already significant at ... double-stranded
DNA containing the major adduct of the anticancer
drug cisplatin. Nature 377, 649–652.
29 Zlatanova J, Yaneva J & Leuba SH (1998) Proteins that
specifically...