Báo cáo khoa học: Endogenous tetrahydroisoquinolines associated with Parkinson’s disease mimic the feedback inhibition of tyrosine hydroxylase by catecholamines doc
Báo cáo khoa học: Endogenous tetrahydroisoquinolines associated with Parkinson’s disease mimic the feedback inhibition of tyrosine hydroxylase by catecholamines doc
... characterization of the blue-green ratphaeochromocytoma (PC12) tyrosine hydroxylase with a dopamine–Fe(III) complex. Reversal of the endoge-nous feedback inhibition by phosphorylation of serine-40. ... mechanisms of TH feedback inhibition FEBS Journal 275 (2008) 2109–2121 ª 2008 The Authors Journal compilation ª 2008 FEBS 2121 Endogenous tetrahydroisoquinolines associated with Parkinson’s disease mimic ... reduced level of activityDA and other catecholamines have a stabilizing effecton the conformation of TH [33]. We therefore com-pared the thermostability of hTH at 37 °C in the pres-ence of NMNorsal,...
- 13
- 487
- 0
Tài liệu Báo cáo khoa học: Emerging pathways in genetic Parkinson’s disease: Autosomal-recessive genes in Parkinson’s disease – a common pathway? docx
... lead to these diseasesand will be a major step forward in our understanding of the pathogenesis of PD and ultimately to the development of novel therapeutic approaches.Acknowledgements The authors ... mutations causing familial forms of Parkinson’s disease have provided insight into the molecular mechanisms that underlie the genetic and sporadic forms of this disease. Loss of protein function result-ing ... cases with disease onset before the age of 20[2]. Clinically, PD patients with mutations in PARK2suffer a slow progression of the disease commonly associated with early-onset dystonia and are...
- 9
- 775
- 0
Tài liệu Báo cáo khoa học: Emerging pathways in genetic Parkinson’s disease: Potential role of ceramide metabolism in Lewy body disease pptx
... together datasuggesting that some of the genes involved in the genetics of Lewy body disease, have in common the fact that they impinge on ceramide metabolism. Oneshortfall of the present theory ... metabolism.Levels of cellular ceramide are regulated by the de novo pathway and the recycling pathway. The formerrelates to the synthesis of ceramide through the conden-sation of palmitate and ... characterized by the disruption of cellularmechanisms leading to the accumulation of iron in the basal ganglia. Mutations in the gene PLA2G6 wererecently described as the cause of NBIA-2 [22]....
- 7
- 652
- 0
Tài liệu Báo cáo khóa học: Point mutations associated with insecticide resistance in the Drosophila cytochrome P450 Cyp6a2 enable DDT metabolism doc
... effect of these mutations on the electrontransfer process. To elucidate the mechanism by whichmutations on the J helix and in the vicinity of the b sheet 3–3can affect the catalytic properties of ... had no effect on the spectra. The type of substrate-induced binding spectra was determined by the positions of the peak and the valley on the spectrum [43].Sequence alignment The alignments between ... obtained with the CLUSTALXsoftware. Toobtain information about the spatial positions of the mutations, their similar positions were determined on the structure of CYP102A1, this protein is the most...
- 8
- 535
- 0
Tài liệu Báo cáo khoa học: DNA modification with cisplatin affects sequence-specific DNA binding of p53 and p73 proteins in a target site-dependent manner pptx
... and the ability of the particular p53target site to accommodate the cisplatin IACs. The higher the probability of formation of the cisplatinIACs within the p53DBSs due to the occurrence of the ... treated with the drug in excess of nonspecific calf thymus DNA. Inter-action of the protein with any of these targets was sig-nificantly affected by the cisplatin treatment, but the levels of inhibition ... 85% of the p21b target was bound by the protein,respectively, when compared to the untreated p21b. The behavior of the PGM4 site was similar to that of p21b, showing practically no inhibition of...
- 14
- 597
- 0
Báo cáo khoa học: "Discriminative Language Modeling with Conditional Random Fields and the Perceptron Algorithm" pptx
... best-scoringhypothesis ziis found, and if it differs from the refer-ence yi, then the cost of each feature2is increased by the count of that feature in ziand decreased by the count of that feature ... that the construction of the language model requires two choices. The firstconcerns the choice of the set of n-gram features Φifori = 1 . . . d implemented by D. The second concerns the choice ... is the WER at the iteration with the best objective function value in the interval (x-20,x]. the CRF algorithm. In the first two trials, the trainingset consists of the pruned lattices, and the...
- 8
- 458
- 0
Báo cáo khoa học: "Complementing Word Net with Roget''''s and Corpus-based Thesauri for Information Retrieval" pdf
... is the frequency of noun nj occurring as the argument of adjective ai, fadj(nj) is the frequency of the noun nj oc- curring as the argument of any adjective, f(ai) is the frequency of the ... frequency of noun nj occurring as the subject of verb vi, L~,b(n~) is the frequency of the noun nj occurring as subject of any verb, f(vi) is the frequency of the verb vi, and Nsub is the ... probabilities of P(a) and P(b) are esti- mated by counting the number of occurrences of a and b in documents and normalizing over the size of vocabulary in the documents. The joint probability...
- 8
- 263
- 0
Báo cáo khoa học: A new rice zinc-finger protein binds to the O2S box of the a-amylase gene promoter pptx
... pLGD17-265UP1wasusedasthebaitwithaninsertion of three copies of the O2S domain at the 5¢ end of the CYC1 mini-promoter region. Following transfor-mation of the URA-marked plasmid pLGD-265 UP1containing the ... specifically to the O2S elemen t. Wehave also determined the importance of the amino acidswithin the binding domain of RAMY protein and analyzed the time course for the induction of RAMY a nd ... family of proteins is further characterized by a highly conserved motif of 12 amino acids with the consensus WAPDPVTGYYRP.RAMY can be grouped into the Lea529familybasedonthepresence of the canonical...
- 7
- 359
- 0
Báo cáo khoa học: Full-length adiponectin protects hepatocytes from palmitate-induced apoptosis via inhibition of c-Jun NH2 terminal kinase doc
... ifso, whether this involved: (a) augmentation of the unfolded protein response (UPR); (b) up-regulation of members of the inhibitor of apoptosis protein (IAP)family; and ⁄ or (c) inhibition of JNK ... and the ability of PI3 kinase ⁄ Akt to suppress the c-Jun NH2terminal kinase (JNK) pathway has been studied in avariety of cell types [20]. Therefore, excess lipid deliv-ery together with the ... abolished the effects of adiponectin. Adiponectin-induced inhibition of palmitate- and thapsigar-gin-induced apoptosis was not the result of an augmentation in the unfolded protein response or the...
- 7
- 199
- 0
Báo cáo khoa học: Krit 1 interactions with microtubules and membranes are regulated by Rap1 and integrin cytoplasmic domain associated protein-1 doc
... and binds to PIP2 The molecular modelling of the last 300 amino acidresidues of Krit1 that we generated corroborates the existence of a FERM domain at the C-terminus of the protein. FERM domains ... cleft on the Krit1 FERM model thatwe generated. Mutagenesis analyses of these residueswill help to determine whether the binding site of the polar head of PIP2on Krit1 is similar to that of radixin.Many ... beinvolved in the shuttling of Krit1 between the micro-tubules and the nucleus. Remarkably, the contribution of these two sites to the binding to MT is additive(Fig. 6A). Because we show that the N-terminus...
- 15
- 329
- 0
Từ khóa: Báo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018Nghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDENghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùngTìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXChuong 2 nhận dạng rui roTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2Tranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)chuong 1 tong quan quan tri rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtHIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀMMÔN TRUYỀN THÔNG MARKETING TÍCH HỢP