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Báo cáo khoa học: Peroxiredoxins as cellular guardians in Sulfolobus solfataricus – characterization of Bcp1, Bcp3 and Bcp4 pot

Báo cáo khoa học: Peroxiredoxins as cellular guardians in Sulfolobus solfataricus – characterization of Bcp1, Bcp3 and Bcp4 pot

Báo cáo khoa học: Peroxiredoxins as cellular guardians in Sulfolobus solfataricus characterization of Bcp1, Bcp3 and Bcp4 pot

... analysis of bcp1, bcp3 and bcp4 under oxidative stressThe involvement of bcp1, bcp3 and bcp4 in oxidativestress was investigated by assessing mRNA levels fol-lowing treatment of S. solfataricus ... thermophilicity of recombinant Bcp1, Bcp3 and Bcp4, we investigated the peroxidaseactivities of the enzymes by measuring H2O2removalat increasing temperatures. Bcp1 and Bcp3 activitywas shown ... redoxhomeostasis of photosynthesis [18]; by contrast, the Bcp3 sequence only shows one cysteine at position 42 in the N-terminal region.Expression and purification of Bcp1, Bcp3 and Bcp4 bcp1, bcp3 and bcp4...
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Báo cáo khoa học: Cdc37 maintains cellular viability in Schizosaccharomyces pombe independently of interactions with heat-shock protein 90 doc

Báo cáo khoa học: Cdc37 maintains cellular viability in Schizosaccharomyces pombe independently of interactions with heat-shock protein 90 doc

... [6]. A complex consisting of the interacting domains of yeast Hsp90 and humanCdc37 has been crystallised and its structure deter-mined [16]. Amino acids 16 4–1 70 and 20 4–2 08 of human Cdc37 were ... (p50); an N-terminal domainconsisting of amino acids 1–1 26, a middle region com-posed of residues 12 8–2 82 and a C-terminal domain of amino acids 28 3–3 78 [8]. By aligning human and S. pombe Cdc37 ... mine the identity and location of the nucleotide insertion.Four mutants obtained contained in- frame insertionsresulting in the insertion of five amino acids into the Cdc37protein. Stop...
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Báo cáo khoa học: Nanoparticles can induce changes in the intracellular metabolism of lipids without compromising cellular viability docx

Báo cáo khoa học: Nanoparticles can induce changes in the intracellular metabolism of lipids without compromising cellular viability docx

... sig-naling for hypoxia was of interest in this studybecause QDs, which are redox-active NPs, can releaseCd2+ and induce the intracellular formation of ROS, and, as such, make good candidates ... resulting in an increase in glucose uptake and an up-regulation of glycolysis[37,38]. In addition, PI3K signaling has been shown tobe involved in the up-regulation of lipogenic enzymes,such as ... forming multiplecytoplasmic LDs (Fig. 1B–D). The number of LDsincreased with increasing concentration of QDs(Fig. 1E). Within this time period, cells exposed torelatively low concentrations of...
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Báo cáo khoa học: Homoadenosylcobalamins as probes for exploring the active sites of coenzyme B12-dependent diol dehydratase and ethanolamine ammonia-lyase docx

Báo cáo khoa học: Homoadenosylcobalamins as probes for exploring the active sites of coenzyme B12-dependent diol dehydratase and ethanolamine ammonia-lyase docx

... containing 0.2M ethanolamine and 5 mM 2-mercaptoethanol, in a volume of 1.0 mL. Spectra were measured at 5 min of incubation(solid lines). Spectra of the denaturated and neutralized (dotted lines) ... cobalamin. The regions shown byoblique lines and shadows indicate theadenine-binding pocket and the cobalamin-binding site of enzyme, respectively.Coenzymic functions of homoadenosylcobalamins ... mechanism-based inactivation of diol dehydrataseby 3¢,4¢-anhydroadenosine has been reported [51].The evidence for the hypothetical adenine-bindingsite was first obtained by biochemical binding experi-ments...
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Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer ppt

Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer ppt

... ligand-binding domain; a transmembranedomain; an intracellular tyrosine kinase domain; and aC-terminal regulatory domain [2]. The extracellulardomain is subdivided further into four domains. ... ligand binding, as in thecase of EGFR vI. EGFR vIII is reported to occur in 3 0–5 0% of glioblastomas [6]. In lung cancers, EGFRvIII is found in 5% of squamous cell carcinomas, whilenone of ... EGFR(including EGF, transforming growth factor-a, amphi-regulin and epigen); (b) those that bind to EGFR and ERBB4 (including betacellulin, heparin-binding EGF and epiregulin); and (c) neuregulin...
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Tài liệu Báo cáo khoa học:

Tài liệu Báo cáo khoa học: "Enhanced word decomposition by calibrating the decision threshold of probabilistic models and using a model ensemble" pdf

... ourexperimental setup. Instead of dividing datasetsduring 10-fold cross-validation into training and test subsets with the ratio of 9:1 we randomly splitthe data into training, validation and test sets ... increasing experience In our first experiment we applied 10-fold cross-validation on datasets ranging from 500 to 2500words with the goal of measuring how the learningimproves with increasing ... a net increase of 0.0819 of correct boundaries which led to the in- creased recall. Since the deduction of precisionis less than the increase of recall, a better over-allperformance of PROMODES-H...
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Báo cáo khoa học: C fi G base mutations in the CArG box of c-fos serum response element alter its bending flexibility Consequences for core-SRF recognition potx

Báo cáo khoa học: C fi G base mutations in the CArG box of c-fos serum response element alter its bending flexibility Consequences for core-SRF recognition potx

... effect of bending strainThere are several indications of a redistribution of the strains exerted on the oligonucleotide by thebend: partial unstacking of some adenine, thymine and guanine bases and ... cm)1(dT) in response to basedestacking in the oligonucleotides [29,30,4 1–4 3,4 5–4 9].Between 10 and 25 °C, within the premelting domain,spectral changes are reflected in a gradual increase in the ... with a broadband around 1400 cm)1at 25 °C of about the sameintegral intensity, indicating a larger population of lin-ear conformers. The upshift and increase in intensity of the peak at...
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Báo cáo khoa học: A ribonuclease zymogen activated by the NS3 protease of the hepatitis C virus potx

Báo cáo khoa học: A ribonuclease zymogen activated by the NS3 protease of the hepatitis C virus potx

... higher than that of the unactivated 2C zymogen, and the difference is again the result of both a decrease in kcat and an increase in Km. The increase in kcatonactivation of the 1C and 2C zymogens ... stability of the 1Czymogen increases on activation, perhaps as the result of the release of strain.Affinity for ribonuclease inhibitor and cytotoxicityRI recognizes members of the RNase A superfamilywith ... [methyl-3H]thymidine for 4 h, and theincorporation of radioactive thymidine into the cellular DNA was quantified by liquid-scintillation counting.Results were the percentage of [methyl-3H]thymidine incor-porated...
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Báo cáo khoa học: Key substrate recognition residues in the active site of a plant cytochrome P450, CYP73A1 ppt

Báo cáo khoa học: Key substrate recognition residues in the active site of a plant cytochrome P450, CYP73A1 ppt

... with the cinnamate. In conclusion, a combination of homology modelling and site-directed mutagenesis of CYP73A1 has identifiedN302 and I371 as key determinants of substrate binding and orientation ... mutagenesis of the involve-ment of some of these residues in the docking and catalysis of cinnamic acid. The impact of the active site mutations onthe binding and metabolism of cinnamic acid ... I371K,50-fold in I371F and 100-fold in N302D. In contrast,increases in binding efficiency are observed for a few ligandsafter modification of the protein. The most notable increasesare 15-fold...
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Báo cáo khoa học: Alpha 1-antichymotrypsin/SerpinA3 is a novel target of orphan nuclear receptor Nur77 potx

Báo cáo khoa học: Alpha 1-antichymotrypsin/SerpinA3 is a novel target of orphan nuclear receptor Nur77 potx

... of the serine protease inhibitorfamily, and is involved in the in ammatory response.It is mainly synthesized in the liver [14] and is a posi-tive acute-phase reactant. During the acute phaseresponse, ... is composed of three typical functional domains:an N-terminal region (transactivation function 1,AF-1), a DNA-binding domain, and a ligand-bindingdomain. Nur77 has no specific ligand discovered ... )175) was a Nur77-specific bindingsite. (A) In vitro expression of Nur77 was confirmed by westernblot. (B) EMSA was used to assess the binding of in vitro producedNur77 to the double-stranded32P-labeled...
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