... blood–brainbarrier, and in placental trophoblasts, testis and bonemarrow, it provides protection of vital body parts and, in the gut, liver and kidney, Pgp helps to eliminate tox-ins from the body ... 4-chloro-7-nitro-2,1,3-benzoxadiazole (NBD-Cl) and MK571 and, to a lesser extent, byATP depletion, indomethacin, probenecid and vanadate. All the inhibitors,apart from NBD-Cl, are known to modulate multidrug ... [15–18]. On the other hand, MRP1is present in virtually all human tissues and in mosthuman tumor cell lines and tumor samples [4]. Usingmice genetically deficient in both the mdr1a and mdr1bgenes...