Báo cáo khoa học: Role of DptE and DptF in the lipidation reaction of daptomycin ppt
Báo cáo khoa học: Role of DptE and DptF in the lipidation reaction of daptomycin ppt
... proteins(ACPs) [14,15]. The genes dptE and dptF are localized immediatelyupstream of the NRPSs of A21987C. The resultingproteins DptE and DptF were predicted to beinvolved in the lipidation reaction based ... the initiation module of dapto-mycin. That DptE and DptF are involved in the lipidation process of daptomycin was first shown byMiao et al. [1]. In their work, the daptomycin genecluster was ... DptF by DptE in trans is basedon specific protein–protein interactions, as DptF is favored over other acylcarrier proteins. Study of DptE and DptF may provide useful insights into the lipidation...
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Tài liệu Báo cáo khoa học: Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity pptx
... promoting an increase in proopiomelanocortin and cocaine and amphetamineregulated transcript. Taken together, these findingsprovide a compelling argument for the role for malo-nyl-CoA in regulating ... nutrient sensing in the brain and is an example of an enzyme that can sense and respond to the nutritional environment. The majorchallenge to understanding the role of CPT1c is todetermine its enzymatic ... fluctuations in the levels of blood glucose [13], fattyacids [12,14,15] and certain amino acids [16].A linkage between fatty acid synthesis in the CNS and feeding behavior was uncovered with the findingthat...
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Tài liệu Báo cáo khoa học: "Subgrammars, Rule Classes and Control in the Rosetta Translation System" ppt
... meanings). 2. the meaning of the rules (rule meanings). In Montague Grammar these meanings are ex- pressed in intensional logic. In the Rosetta system the meanings of rules and basic expressions ... for the compositional and the analytical definition of a language. This is proved by the formal definitions in subsection 6.2. The third problem concerned the consequences of defining the ... M-grammars are divided into subgrammars in a way that was inspired by the programming language Modula-2 on the one hand and by the notion projection from X-theory on the other hand. The second problem...
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Báo cáo khoa học: Amyloid oligomers: dynamics and toxicity in the cytosol and nucleus ppt
... oligomers and interact with other proteins. The improvement of microscopic techniques will promote the understanding of the dynamics and toxicity of mis-folded proteins in living cells in the near ... examination of the polyubiquitination of mutant SOD1 using FRET may be useful for inves-tigating the details of the role of the ubiquitin–protea-some system in neurodegenerative diseases in ... mutant proteins results in increased mis-folding of normal proteins and further enhancement of co-aggregation. In this state, the degradation of mis-folded proteins is diminished by their insolubility,...
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Báo cáo khoa học: Monomeric molten globule intermediate involved in the equilibrium unfolding of tetrameric duck d2-crystallin pdf
... stabilityfor crystallins is essential in maintaining lens transparency[4]. Determining the mechanism of folding and assembly of these proteins is important for understanding how they canform stable ... concentrations. The d2-crystallin in lens was recruited during evolutionfrom argininosuccinate lyase, an enzyme involved in arginine biosynthesis derived from the urea cycle. Thesetwo proteins shared ... conformationalstates in the pathways leading to folding and unfolding areimportant. For d2-crystallin, characterization of the inter-molecular association of the helix bundles and the partialunfolded intermediate...
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Báo cáo khoa học: Cellular response to unfolded proteins in the endoplasmic reticulum of plants pptx
... chain is brefeldin A-insensitive and isinhibited by the proteasome inhibitor clasto-lactacystinb-lactone, resulting in the accumulation of ricinA chains. These stabilized ricin A chains are partlydeglycosylated ... pivotal role of the UPR is to maintain ER home-ostasis. Therefore, the presence of mutated proteinsthat are unable to fold into their native conformation in the ER induces the UPR in an effort ... peptide in the 24-kDa a-zein and the 19-kDa a-zein endosperm storage proteins, respect-ively. These mutant proteins are translocated into the lumen of the ER, but remain anchored to the mem-branes...
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Báo cáo khoa học: Death inducer obliterator protein 1 in the context of DNA regulation Sequence analyses of distant homologues point to a novel functional role docx
... the context of DNA binding and chromatin regulation. These homologues includemembers of the CpG binding protein (CGBP) family of proteins that bind DNA at unmethylated CpGislands [7], which are ... inhi-bitor of growth protein 3 (ING3) PHD, which isanother domain involved in chromatin binding and clearly more divergent (e-value 0.019) from DIDO and the other sequences. As the alignment ... from the other bran-ches, which was indeed predicted. The other maingroup, obtained 97% of the time in 20 740 exploredtrees, contained the DIDO PHD sequences clusteredwith the PHF and the...
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Báo cáo khoa học: A steady-state competition model describes the modulating effects of thrombomodulin on thrombin inhibition by plasminogen activator inhibitor-1 in the absence and presence of vitronectin ppt
... binding of TM by thrombin. Binding of the carboxy-terminal part of the reactive center loop of PAI-1 in the small cleft formedby the 60-loop and VR1 loop can be envisioned. The kinetics of the ... PAI-1/VNcomplexes, suggests the involvement of the chondroitinsulphate of rl-TM in the binding of PAI-1/VN. Indeed,both in the absence and presence of PAI-1, the inter-action of rl-TM with immobilized ... suicide-substrate reaction between thrombin and PAI-1. These findings leavea role for TM open in altering the initial binding stepbetween thrombin and PAI-1 or in changing the ability of thrombin to catalyze subsequent...
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Báo cáo khoa học: Biochemical evidence for conformational changes in the cross-talk between adenylation and peptidyl-carrier protein domains of nonribosomal peptide synthetases ppt
... consisted of the firsttwo functional domains, namely the phenylalanine-specific A domain and the PCP domain. The terminalE domain was excised (the exact amino acid composi-tion of the investigated ... lead to the formation of the amino acylthioester on the Ppant of the PCP domain and prime the enzyme for the next step in the reaction sequence.Therefore, we turned to the sulfamoyl-based inhibi-tor ... by decreasing the rate of cleavagebetween the two subdomains of the A domain. Thesefindings were later explained with the structural modelthat the smaller subdomain AC of the A domainrotates...
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Tài liệu Báo cáo khoa học: Osmotic stress sensing and signaling in fishes doc
... regulator of MAPK cascades, mitogen-activated protein kinasekinase kinase 7 interacting protein 2 (TAK 1 bindingprotein 2 ¼ TAB 2), as an IEG during hyperosmoticstress in tilapia gill epithelium ... gene istransiently and very rapidly (within 2 h) induced byhyperosmotic stress, indicating a role of this mitogen-activated protein kinase kinase kinase 7 interactingprotein for osmosensory ... acute-phase response and alongterm response. The acute-phase response takesplace in the order of minutes to hours and involvesmany hormones, including arginine vasopressin, angio-tensin II, natriuretic...
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Từ khóa: báo cáo khoa học mẫubáo cáo khoa học y họcbáo cáo khoa học sinh họcbáo cáo khoa học nông nghiệpbáo cáo khoa học lâm nghiệpbáo cáo khoa học thủy sảnBáo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018Nghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDETrả hồ sơ điều tra bổ sung đối với các tội xâm phạm sở hữu có tính chất chiếm đoạt theo pháp luật Tố tụng hình sự Việt Nam từ thực tiễn thành phố Hồ Chí Minh (Luận văn thạc sĩ)Tìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinThơ nôm tứ tuyệt trào phúng hồ xuân hươngSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXChuong 2 nhận dạng rui roKiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2chuong 1 tong quan quan tri rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIHIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀMMÔN TRUYỀN THÔNG MARKETING TÍCH HỢPTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲ