Báo cáo khoa học: Arabidopsis thaliana CYP77A4 is the first cytochrome P450 able to catalyze the epoxidation of free fatty acids in plants potx
Báo cáo khoa học: Arabidopsis thaliana CYP77A4 is the first cytochrome P450 able to catalyze the epoxidation of free fatty acids in plants potx
... FEBS. No claim to original French government works 735 Arabidopsis thaliana CYP77A4 is the first cytochrome P450 able to catalyze the epoxidation of free fatty acids in plants Vincent Sauveplane1, ... unsaturated C18 fatty acids. This is also the first report describing a cytochrome P450 whichcan catalyze the epoxidation of free fatty acids in plants. Plants are sessile organisms and therefore relyon ... for an understanding of the physiological role of epoxides of fatty acids in plants. In addition to cytochromes P450, two distinct types of plant enzyme, unrelated to cytochrome P450, withepoxidase...
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Tài liệu Báo cáo khoa học: Arabidopsis thaliana BTB⁄ POZ-MATH proteins interact with members of the ERF⁄AP2 transcription factor family ppt
... BPM1version of 151 amino acids [BPM1(1–151)] comprising the first 38 amino acids of BPM1 followed by the com-plete MATH domain. As shown in Fig. 2A, BPM1(1–151) is entirely capable of binding to GST:RAP2.4, ... assemblewith other proteins either in the nucleus or the cyto-plasm.DiscussionThis work provides novel information, including the first description linking ERF ⁄ AP2 proteins to the BPM family, ... and other BTB proteins [2,16], it remains unclearwhat kind of interactions are mediated by the MATHdomain in plants. In this article, we show that the MATH domain of BPM proteins is used to assemble...
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Báo cáo khoa học: Saporin and ricin A chain follow different intracellular routes to enter the cytosol of intoxicated cells pptx
... C-terminus of PEA is essentialfor the cytotoxicity of the endocytosed toxin, allowingPEA to reach its site of action [2,5]. This implies thatPEA may interact with the KDEL receptor in order to traffic ... oocytes, but the oocytes could be pro-tected from autointoxication by injecting neutralizingantisaporin antibodies into the cytosol [22]. The mechanism(s) underlying this cytotoxicity remainsunclear ... 4987Discussion The therapeutic use of saporin-based immunotoxins[30,31] prompted us to investigate whether saporinwould follow the same route of entry into the cytosol as the related plant toxin ricin...
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Tài liệu Báo cáo khoa học: Olfactory receptor signaling is regulated by the post-synaptic density 95, Drosophila discs large, zona-occludens 1 (PDZ) scaffold multi-PDZ domain protein 1 pptx
... grouped into threemain classes of PDZ binding motifs, occurring at the C-terminus of the interacting proteins [16]. We scanned the human olfactory receptor repertoire for putativebinding motifs ... testedbinding of single PDZ domains 1 + 2, and found thatboth could bind to the OR C-terminus (Fig. 2D).Next, we investigated the ability of PDZ domains1 + 2 to bind to receptor C-termini of 15 ... proteinswithin the cell. We found this translocation to bedependent on the final amino acids of the receptorprotein. Similar to the other PDZ domain interactionsthat have been shown to be abolished...
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Tài liệu Báo cáo khoa học: Rotary F1-ATPase Is the C-terminus of subunit c fixed or mobile? docx
... suggested the unwinding of the single a-helix at the C-terminal portion of c, thus allowingfor unimpaired rotation of the remainder of c.Furthermore, the calculations suggested the very end of c to ... summarized in Fig. 5. The emerging picture is that the central shaft of F1nevercomes to a full halt; c is free to slowly rotate back and forth in the time range of minutes to hours, owing to the ... revealed the possibility of a‘functional unwinding’ of the a-helix to form a swivel joint.Furthermore, they suggested a firm clamping of that part of c even without the engineered cross-link, i.e. in...
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Báo cáo khoa học: VEGF gene expression is regulated post-transcriptionally in macrophages pdf
... cloned into the 3¢ UTR of the luciferasegene of 3.1-luc. The VEGF-FL-luc construct contains nt209–1747 of the mVEGF 3¢ UTR where nt 1 is the first base of the VEGF stop codon [34] (identical to ... 2005)doi:10.1111/j.1742-4658.2006.05106.x The macrophage is critical to the innate immune response and contributes to human diseases, including in ammatory arthritis and plaque formation in atherosclerosis. Vascular endothelial ... evaluated the role of the 3¢ UTR in gene exp-ression by introducing the SmaI ⁄ XbaI fragment (nt209–1747) of the mouse 3¢ UTR into the 3¢ UTR of the luciferase gene. The structure of the full-lengthreporter...
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Báo cáo khóa học: ICAM-1 expression is highly NF-jB-dependent in A549 cells No role for ERK and p38 MAPK docx
... Withinresting cells, NF-jB is retained in the cytoplasm complexed to an inhibitor protein from the IjB family [3]. Stimulationwith pro -in ammatory cytokines, such as tumour necrosisfactor ... protein was rapidlyinduced (Fig. 1). This was first apparent by 2 h poststim-ulation and levels of ICAM-1 protein continued to rise over the 18 h of the experiment. To examine the role of NF-jB in ... NF-jB DNAbinding and NF-jB-dependent transcription To examine the role of the p38 and the ERK MAPKpathways, we examined the effects of the p38 MAPKinhibitor, SB203580, the MEK1 inhibitor, PD098059...
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Báo cáo khoa học: Neuroserpin Portland (Ser52Arg) is trapped as an inactive intermediate that rapidly forms polymers Implications for the epilepsy seen in the dementia FENIB ppt
... inclusions of neuroserpin within c ortical a nd subcorticalneurons [1–3]. Neuroserpin is a member of the serineproteinase inhibitor or serpin s uperfamily. It inhibits the enzyme tissue plasminogen ... Neuroserpin polymers result from the sequentialinsertion of t he reactive centre loop of one molecule intob-sheet A of another [1,6]. The resulting s pecies is inactive asa proteinase inhibitor ... structure. The melting point temperature was determined by mon-itoring the change in CD signal at 216 nm while increasing the temperature at 1 °CÆmin)1(Fig. 5B). In the case of Ser52Arg neuroserpin,...
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Báo cáo khoa học: Androgen receptor function is modulated by the tissue-specific AR45 variant ppt
... leads to glucocorticoid resistance in a number of pathologicalconditions [24]. In the case of the mineralocorticoidreceptor a variant lacking the hinge and ligand-bindingregions but able to increase ... [14]. They are organized in amodular fashion and act by binding to DNAresponse elements found in the regulatory regions of their target genes [14]. Due to the involvement of these receptors in ... linked to the DNA-bind-ing domain (DBD), hinge region and ligand-bindingdomain (LBD) of the AR. The restricted expressionpattern, the inhibitory effect on AR function and the cofactor-dependent...
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Báo cáo khoa học: b-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins pot
... hasbeen shown to form a complex with the adaptor pro-tein Fe65 and the histone acetyltransferase Tip60 that is capable of inducing transcription of reporter genes[44]. The ability to form transcriptionally ... cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminaldomain (ICD) of the APP family of proteins. Biochem-istry 42, 6664–6673.44 Cao X & Sudhof TC (2001) ... generation of the amyloid b-protein is the b-site APP-cleaving enzyme 1 (BACE1). Here, we investigated the effects of genetic manipulation of BACE1 on the processing of the APP family of proteins. BACE1...
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Từ khóa: báo cáo khoa học mẫubáo cáo khoa học y họcbáo cáo khoa học sinh họcbáo cáo khoa học nông nghiệpbáo cáo khoa học lâm nghiệpbáo cáo khoa học thủy sảnNghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longNghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùngTìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinThơ nôm tứ tuyệt trào phúng hồ xuân hươngKiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIĐổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ