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Báo cáo khoa học: The role of evolutionarily conserved hydrophobic contacts in the quaternary structure stability of Escherichia coli serine hydroxymethyltransferase pptx

Báo cáo khoa học: The role of evolutionarily conserved hydrophobic contacts in the quaternary structure stability of Escherichia coli serine hydroxymethyltransferase pptx

Báo cáo khoa học: The role of evolutionarily conserved hydrophobic contacts in the quaternary structure stability of Escherichia coli serine hydroxymethyltransferase pptx

... 132–143 ª 2008 The Authors Journal compilation ª 2008 FEBS 143 The role of evolutionarily conserved hydrophobic contacts in the quaternary structure stability of Escherichia coli serine hydroxymethyltransferase Rita ... at the value determined from the amino acidsequence (45 320 Da).Measurement of the Kd of PLP bindingequilibriumPLP binding equilibria were analyzed taking advantage of the protein intrinsic ... binding properties The affinity of wild-type and mutant forms for the cofactor was measured to evaluate the impact of the mutations on the structure of the PLP binding site.Because PLP binding...
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Báo cáo khoa học:

Báo cáo khoa học: "COMMON TOPICS AND COHERENT SITUATIONS: INTERPRETING ELLIPSIS IN THE CONTEXT OF DISCOURSE INFERENCE" ppt

... with in the treatment of VP-eUipsis, perhaps at the cost of some degree of the- oretical inelegance. However, this aspect was crucial for handling the gapping data, since the infelicity of gapping ... that reinforces one of the meanings. For instance, gapping is felicitous in passage (3), where con- text supports the symmetric reading, but is infelicitous in passage (4) under the intended ... referential forms as to whether they leave behind an empty constituent in the syntax and whether they are anaphoric in the semantics. Empty. constituents in the syntax are not in themselves refer-...
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Báo cáo khoa học: An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid b-protein doc

Báo cáo khoa học: An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid b-protein doc

... deletion of Synoviolin causes a change in the intracellular trafficking of NCT.Effect of Synoviolin on the production of AbNCT is one of the essential cofactors of the c-secretasecomplex. We therefore ... SupportingInformation). We also determined the levels of c-secre-tase-unrelated ER protein (calnexin) and cytoskeletonprotein (tubulin) in these cells as the internal controlproteins. The calnexin ... generation.ResultsAccumulation of immature NCT in synoviolin-nullcellsTo investigate whether Synoviolin is involved in the degradation of PS cofactors, we first compared the levels of PS cofactors by immunoblotting betweensynoviolin-null...
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Báo cáo khoa học: A novel factor XI missense mutation (Val371Ile) in the activation loop is responsible for a case of mild type II factor XI deficiency doc

Báo cáo khoa học: A novel factor XI missense mutation (Val371Ile) in the activation loop is responsible for a case of mild type II factor XI deficiency doc

... explained by the proximity of the mutation to the cleavage site, probably resulting in asmall interference with the binding of the activator to the FXI zymogen.There are some examples of inherited ... activation loop at the N-terminus of the catalyticdomain, are notable. In the zymogen FXI, Ile371 is exposed to the solvent, while in the activated FXI it is inserted into the protein. The picture ... consequences of the Val371Ile substitution. Rib-bon representation of the superimposition between the structures of the catalytic serine protease domain of the zymogen (red) andactivated (green) FXI. The...
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Báo cáo khoa học:

Báo cáo khoa học: "A Feedback-Augmented Method for Detecting Errors in the Writing of Learners of English" docx

... errors since they are based on the articlesand the distinction between singular and plural.Finally, the tagged instances are stored in a filewith their surrounding words. Each line of it con-sists ... 1(a)?modified by one of the words in Table 1(b)?modified by one of the words in Table 1(c)?Figure 1: Framework of the tagging rulesTable 1: Words used in the tagging rules(a) (b) (c) the indefinite article ... detected in thisstep, the rest of the steps are not applied. In the second step, errors are detected by the rules described in Table 3. The symbol “” in Ta-ble 3 denotes that the combination of the...
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Tài liệu Báo cáo khoa học:

Tài liệu Báo cáo khoa học: "A Multimodal Interface for Access to Content in the Home" pdf

... understanding of system capa-bilities. Of the remaining 66% of inputs (2166) which were within the functionality of the system, 68% were in grammar. On the within functionality portion of the data, ... sets of scenarios and then freely interacting with each system. For counterbalancing purposes, half of the subjects used the tablet and then the re-mote control and the other half used the ... select items. The pen can be used both for selecting items (pointing at them) and for handwritten input. The graphical user interface has three main screens. The main screen is the search screen...
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Báo cáo khoa học: Insights into substrate and product traffic in the Drosophila melanogaster acetylcholinesterase active site gorge by enlarging a back channel ppt

Báo cáo khoa học: Insights into substrate and product traffic in the Drosophila melanogaster acetylcholinesterase active site gorge by enlarging a back channel ppt

... hinder the entrance of acetylcholine to the CAS in the wild-type enzyme, it appears that, in the two mutants(Trp83Ala ⁄ Glu), inhibitors that bind to the PAS didnot prevent the entrance of ... mutants: the strong decrease of inhibition of propidium [21] and the increase of remaining activity upon peripheral site saturation byfasciculin [24].Finally, minor deviations of pS curves upon binding of ... used the specific equation in Scheme 1. The effect of two ligands on the activity of the wild-type DmAChE was evaluated by the equation in Scheme 1 enlarged by the intermediates, repre-senting the...
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Báo cáo khoa học: Evidence for two different electron transfer pathways in the same enzyme, nitrate reductase A from Escherichia coli potx

Báo cáo khoa học: Evidence for two different electron transfer pathways in the same enzyme, nitrate reductase A from Escherichia coli potx

... fumarate reduction; the use of the quinol-binding site inhibitor HOQNO shows that the inhibitor blocks binding of MQH2at the QPsite [27].Study of the reduction and oxidation of the cytochromehas ... determine binding sites of quinols,inhibition by HOQNO (a structural analogue of menaqui-none), did not allow them to see the binding site of ubiquinol because HOQNO is not an inhibitor for the ubiqinones. ... advantage of notdiluting the reducing solutions, thus allowing the addition of smaller quantities for the same reducing effect. In any event, the results obtained are equivalent whatever the mode of reduction...
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Báo cáo khoa học: H2O2, but not menadione, provokes a decrease in the ATP and an increase in the inosine levels in Saccharomyces cerevisiae An experimental and theoretical approach pot

Báo cáo khoa học: H2O2, but not menadione, provokes a decrease in the ATP and an increase in the inosine levels in Saccharomyces cerevisiae An experimental and theoretical approach pot

... accompanied by an increase in the rate of synthesis of Ino, without any need to modify the kineticparameters or activities of the enzymes involved in the pathway from ATP to Ino.Being aware of the simplifications ... that (a) the main if not unique source of inosine is the intracellularpool of adenine nucleotides, (b) the decrease in ATP and the increase in inosine, promoted by H2O2, cannot be explainedsolely ... concentration in a metabolic path-way as a function of the kinetic constants of the enzymesinvolved in that pathway [3]. Application of this methodpointed to the inhibition of the rate of synthesis of...
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Báo cáo khoa học: Calpain 1–titin interactions concentrate calpain 1 in the Z-band edges and in the N2-line region within the skeletal myofibril doc

Báo cáo khoa học: Calpain 1–titin interactions concentrate calpain 1 in the Z-band edges and in the N2-line region within the skeletal myofibril doc

... to peroxidase labelling,density increasing of the Z-line, in particular at the edges of the structure, confirms the immunofluorescentstaining. On the other hand, labelling of the Z-bandregion ... thoselocating calpain 1 at the midpoint of the I-band, pro-vide reasonable evidence to support the interaction of the protease within the 800 kDa fragment. The binding interaction of calpain 1 with ... (2001)Binding of gelsolin domain 2 to actin. An actin interfacedistinct from that of gelsolin domain 1 and fromADF ⁄ cofilin. Eur J Biochem 268, 6165–6175.Calpain 1–titin interactions in myofibrils...
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Từ khóa: Nghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longPhát hiện xâm nhập dựa trên thuật toán k meansNghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùngNghiên cứu khả năng đo năng lượng điện bằng hệ thu thập dữ liệu 16 kênh DEWE 5000Tìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinThơ nôm tứ tuyệt trào phúng hồ xuân hươngSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2Nguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Trách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)BÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘITÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ