Báo cáo khoa học: Effect of ﬂanking bases on quadruplex stability and Watson–Crick duplex competition pptx

... quadruplex stability and Watson–Crick duplex competition has not been addressed. We have studied in detail the effect of flanking bases on quadruplex stability and on duplex formation by theG -quadruplex ... on each side bynumerous bases. The effect of loop length and composition on quadruplex conformation and stability has been well investigated in the past, but the effect of flanking bases on quadruplex ... al. Effect of flanking bases on quadruplex stability and Watson–Crick duplex competition FEBS Journal 276 (2009) 3628–3640 ª 2009 The Authors Journal compilation ª 2009 FEBS 3629 stability and quadruplex...

Báo cáo khoa học: Effect of valine 106 on structure–function relation of cytosolic human thymidine kinase Kinetic properties and oligomerization pattern of nine substitution mutants of V106 ppt

... dimerization region of HSV1-TK.Aminoacid106ispositionedinanareaofTK1that is (a) highly conserved among vertebrates and viruses of the pox family and may be important for the regulation and substrate ... Effect of valine 106 on structure–function relation of cytosolic humanthymidine kinaseKinetic properties and oligomerization pattern of nine substitution mutants of V106Hanne ... eluted as a mixture of a dimer and a tetramer.For further investigation of the role of size, conformation and polarity of amino acid 106 for the function and structure of human TK1, we created nine...

Báo cáo khoa học: Effect of magnesium ions on the activity of the cytosolic NADH/cytochrome c electron transport system pptx

... their effect on the oxidation of exogenous NADH.Magnesium-dependent binding of exogenouscyto-c and release of endogenous cyto-cThe effect of Mg2+ on the distribution of both endog-enous and ... hypotonicFig. 1. Effect of magnesium ions on exogenous NADH oxidation by mitochondria incubated in isotonic and hypotonic media. Rat liver mito-chondria (3 mg protein) were incubated in 3.0 mL of ... ascertain the role and effect of magnesium ions on the activity of thecytosolic NADH/cyto-c electron transport system of mitochondria incubated in isotonic 250 mm sucrose and hypotonic 25 mm sucrose...

Báo cáo khoa học: "Effect of Utilizing Terminology on Extraction of Protein-Protein Interaction Information from Biomedical Literature" ppt

... specialized dictionary by com-piling on- line glossaries, and have ap-plied it for information extraction. Weconducted preliminary experiments on one hundred sentences, and compared theextraction performance ... Effect of Utilizing Terminology on Extraction of Protein-ProteinInteraction Information from Biomedical LiteratureJunko HosakaJudice L.Y. KohAkihiko KonagayaRIKENInstitute ... performance when (a) usingonly a general dictionary and (b) usingthis plus our specialized dictionary. Con-trary to our expectation, using only thegeneral dictionary resulted in better per-formance...

Báo cáo khoa học: Effects of cardiomyopathic mutations on the biochemical and biophysical properties of the human a-tropomyosin docx

... additional contributions to the understanding of the effects of these mutations on the clinical symptoms of patients carrying cardiomyopathic Tms.Experimental proceduresConstruction of expression ... absence of troponin as a function of tropomyosinconcentration, and in the presence of troponin and Ca2+concentration varying from 10)6to 10)3M. InorganicÓ FEBS 2004 Cardiomyopathic mutations ... by varying the concen-tration of Tm in the presence of constant concentration of F-actin and myosin S1. In this condition, Tm inh ibits theATPase activity as its concentration increases [33]....

Báo cáo khoa học: " Effect of the medical emergency team on long-term mortality following major surgery"

... linezolid and glycopeptides only, and Stenotropho-monas maltophilia, sensitive to ofloxacin only. Polymicrobialwound contamination also included contamination with fungi(for instance, Candida ... Near-drowninginvolved the aspiration of immersion fluids, marine and soildebris into the respiratory tract and all patients displayed signs of pneumonitis and pneumonia upon arrival. Three patientspresented ... (29%), and head (18%). Two-thirds of patients had combined injuriesto the thorax (for instance, pneumo-/hemopneumothorax),including intrapulmonary contusions and lesioning, and frac-tures of the...

Báo cáo khoa học: "Effect of intern’s consecutive work hours on safety, medical education and professionalism"

... attentional failures after they had been working formore than 16 hours on the traditional schedule [2].Letter Effect of intern’s consecutive work hours on safety, medicaleducation and professionalismChristopher ... hours or more consecutive workare unsafe. Efforts to reduce work hours should focus first and foremost not on the frequency of extended-duration workshifts, but on the duration of consecutive work ... interventions on the performance of upper-levelresidents and other medical staff across a variety of disciplines. We likewise agree that optimizing patient hand-offs, medical education, and trainees’...

Tài liệu Báo cáo khoa học: Effect of siRNA terminal mismatches on TRBP and Dicer binding and silencing efﬁcacy pdf

... impact of silencingTRBP and Dicer on the function of the fully paired and mismatched sequences, we wished to examineFig. 1. Effect of guide strand 5¢ end mismatch on silencing efﬁcacy of siRNAs. ... characterization of Dicer and TRBP complexes.Fig. S5. Effect of a terminal mismatch at the guidestrand 5¢ end on siRNA–TRBP complex formation(sequence 306).Fig. S6. Effect of a terminal mismatch ... mRNA or a non-targeting (NT) siRNA at a ﬁnal concentration of 10 nM. Fluorescence was measured 24 h aftertransfection. The mean and standard deviation are shown for each condition. Asterisks...

Tài liệu Báo cáo khoa học: Effect of ionic strength and oxidation on the P-loop conformation of the protein tyrosine phosphatase-like phytase, PhyAsr docx

... absence of ligand, the WPD loop of PTP1B and RPTPa adoptsan open (inactive) conformation, and upon ligand bind-ing, it adopts a closed (active) conformation (Fig. 3A).In oxidized PTP1B [12,13] and ... of InsP6to PhyAsr (Table 1). Given the absence of structural changes as a function of ionic strength and ligand binding, the effect of ionic strength on catalyticactivity is probably not of ... 136.4) and the wtorsion angle of Gly255 (18.9 to )157.9) upon oxida-tion. This large rotation of the peptide bond betweenAla254 and Gly255 results in a 4.12 A˚movement of Gly255 Ca and a...

Tài liệu Báo cáo khoa học: Effect of deletion of the DNase I hypersensitive sites on the transcription of chicken Ig-b gene and on the maintenance of active chromatin state in the Ig-b locus docx

... role of this region in the transcription of theIg-b gene. Deletion of region III decreased the expres-sion of Ig-b mRNA to 40% of the expression in prede-letion cells (Fig. 4A). Region III ... hybridization. Position of the probes, the size and position of restriction fragments hybridizable with the probe, and exon ⁄ introns areshown as in Fig. 2A. Positions of the DT40 speciﬁc-DHSs and ... estab-lishment and maintenance of acetylation in the GHlocus. Because deletion of this region has no effect on the formation of cell type-speciﬁc DHSs, the regionrequired for H3 and H4 acetylation does...

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