... Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan
Identification of epidermal growth
factor, epidermal growth factor
receptor and ERBB family proteins
Epidermal growth factor (EGF) was originally ... sensitivity in lung cancer. Cancer
Sci 98, 181 7–1 824.
13 Kosaka T, Yatabe Y, Endoh H, Kuwano H, Takahashi
T & Mitsudomi T (2004) Mutations of the epider...
... K, Uchida Y, Koyama
N, Murayama Y, Tanaka T, Miyazawa H, Nagata M,
Kanazawa M et al. (2006) Gefitinib for non-small-cell
lung cancer patients with epidermal growth factor
receptor gene mutations ... phase II study of
gefitinib in non-small cell lung cancer with epidermal
growth factor receptor gene mutations. Lung Cancer 64,
31 4–3 18.
22 Morita S, Okamoto I, Kobayas...
... Epidermal growth factor receptor-regulated
miR-12 5a- 5p – a metastatic inhibitor of lung cancer
Guofu Wang
1,2
, Weimin Mao
1
, Shu Zheng
2
and Jingjia Ye
2
1 Department of Respiratory Disease, ... expression of several downstream genes of epidermal
growth factor receptor signaling. Importantly, examination of lung cancer
samples revealed a signi...
... Miyazawa K, Tsubouchi H, Naka D, Takahashi K,
Okigaki M, Arakaki N, Nakayama H, Hirono S,
Sakiyama O, Takahashi K et al. (1989) Molecular
cloning and sequence analysis of cDNA for human
hepatocyte ... expression of human
hepatocyte growth factor. Nature 342, 44 0–4 43.
6 Miyazawa K, Kitamura A, Naka D & Kitamura N
(1991) An alternatively processed mRNA generated
from human hepat...
... TA, Cruz CP, Fan CY, Brown AT,
Wang Y, Eidt JF & Moursi MM (2003) Saratin, an
inhibitor of collagen–platelet interaction, decreases
venous anastomotic intimal hyperplasia in a canine
dialysis ... of
von Willebrand factor- dependent platelet adhesion,
decreases platelet aggregation and intimal hyperplasia in
a rat carotid endarterectomy model. J Vasc Surg 34,
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20 Smi...
... substrates
pro-hepatocyte growth factor and pro-macrophage-stimulating protein.
Abbreviations
EGF, epidermal growth factor; HAI, hepatocyte growth factor activator inhibitor; HGFA, hepatocyte growth ... HGFA (96 kDa) has the same
domain architecture as coagulation factor XII: an
N-terminal fibronectin type II domain, an epidermal
growth factor (EGF)-like domain, a fibr...
... the nuclear fraction after 5 min of ligand
stimulation and the amount of nuclear Smad3 increases
with prolonged growth factor treatment, reaching a maxi-
mum after 1 5–3 0 min of stimulation with ... #1D11) was purchased from R&D Systems. Details
of polyclonal antisera against Smad2 (anti-S2), Smad3
(anti-S3) and C-terminally phosphorylated forms of
Smad1 (anti-PS1) and...
... Inactivation of
human plasma kallikrein and factor XIa by protein C
inhibitor. Biochemistry 27, 423 1–4 237.
8 Wakita T, Hayashi T, Tamaru H, Nishioka J, Akita
N, Asanuma K, Kamada H, Gabazza EC, ... plasma of normal individuals. Thus, PCI
may play a role as a potent inhibitor of HGFA and APC in plasma and ⁄ or
at the sites of tissue injury in the regulation of tissue reg...