... determining region; ETNF-6-H, heavy chain of ETNF-6 mAb; HSA, human serum albumin; hTNF-a, human tumor necrosis factor-a; TNF-a, tumor necrosis factor-a; TNF-b, tumor necrosis factor-b; VIP, vasoactive ... 3823–3832 ª 2010 The Authors Journal compilation ª 2010 FEBS Catalytic digestion of human tumor necrosis factor-a by antibody heavy chain Emi Hifumi1,2, Kyohei Higashi3and Taizo Uda2,31 ... a light chain of 41S-2 mAb cleaving an HIV-1 env gp41 molecule. They also succeeded in the pro-duction of catalytic antibody light and ⁄ or heavy chainscapable of the degradation of urease...