... wereport the results of the structural studies of the panto-ate-bound form of the N-terminal domain of E. coli PS (nPS). The structure and substrate-binding interac-tions of E. coli nPS have been ... effects of one of the substrates, i.e. pantoate [8,9]. One of theinteresting features of the plant PSs is the presence of a conserved 24 residue insertion in the sequence [9].This sequence of amino ... using thestructures of PSs from E. coli and M. tuberculosis.Structural analysesAnalysis of the sites of substrate binding from NMR data,and structural comparison of the E. coli, M. tuberculosisand...