Báo cáo khoa học: Alternative splicing: role of pseudoexons in human disease and potential therapeutic strategies pot

... in human disease FEBS Journal 277 (2010) 841–855 ª 2010 ICGEB Trieste (Italy) Journal compilation ª 2010 FEBS 855MINIREVIEW Alternative splicing: role of pseudoexons in human disease and potential ... thedevelopment of novel splicing-based therapeutic agentsto treat HIV-1 infections [73]; and new methods in theglobal analysis of alternative splicing proﬁles [74]. Wedecided to examine the role of pseudoexons ... recognition in the normal splicingprocess [55]. First, U1snRNP binding to an intronicsplicing processing element has been found to inhibitpathological pseudoexon inclusion in intron 20 of theATM...

Báo cáo khoa học: Alternative splicing: regulation of HIV-1 multiplication as a target for therapeutic action docx

... further understanding of infection, spread and dissemination through splicing regulation. Such stud-ies coupled with the testing of splicing inhibitors should help the develop-ment of new therapeutic ... and to site A3 inhibition [36].Enzymatic and chemical probing revealed theoccurrence of several SC35 and SRp40 binding sites in SLS3 and in agreement with the strong activationproperties of ... role of proteinhnRNP A1 and the SR proteins SF2 ⁄ ASF, SC35 and SRp40 in these regulations.Targeting splicing as a novelantiretroviral therapyAs stated above, the RNA binding proteins Tat and Rev...

Tài liệu Báo cáo khoa học: A possible role of mitochondria in the apoptotic-like programmed nuclear death of Tetrahymena thermophila Takashi Kobayashi and Hiroshi Endoh docx

... concen-trations (5 and 10 mm)ofMg2+inhibited the DNAcleavage activity (Fig. 4C, lane 4 and 5) and weak inhi-bition was observed even in 1 mm of Mg2+(comparelane 2 and 3 in Fig. 4C), indicating a different ... caspase-8- and caspase-9-like activities, which appear to be involved in the ﬁnalresorption of the parental macronucleus during PND in T. thermophila, and suggested the involvement of mitochondria in ... proposed an involvement of mitochon-dria in PND from the results of preliminary experi-ments with the DePsipher dye, which is useful fordetecting the loss of membrane potential in mitochon-dria...

Báo cáo khoa học: Alternative splicing: good and bad effects of translationally silent substitutions pdf

... field for the investigation of the ele-ments involved in splicing regulation and the integra-tion of all these approaches will give us the bestchance of finally understanding the splicing mechanismitself.An ... altering the essential protein func-tion are produced. In this review we briefly describe the current under-standing in the field and discuss emerging directions in the study of thesplicing mechanism ... to demonstrate purifyingselection at silent sites in the gene of interest and todemonstrate that such constraint is necessary to main-tain correct splicing of the gene. In fact, although we...

Tài liệu Báo cáo khoa học: The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription pdf

... theMuvB proteins Lin-37, Lin-52, Lin-54 and chromatin-associated Lin-9 and Lin-53 ⁄ RBBP4 ⁄ RbAp48.Furthermore, A-Myb and B-Myb were present in immunoprecipitations for Lin-9, Lin-37 and Lin-54[90,92]. ... repression of genes, such as cyclinA and cyclin B1, in dividing cells [92]. Furthermore,depletion of Lin-9 and B-Myb in p53) ⁄ )MEFs causedlowered expression of cyclin A, cyclin B and Cdc2 [94]. In ... complexes of cyclin-dependent kinases (cdks) and their corresponding cyclins. A prominent example of such a pair is cyclin B and cyclin-dependentkinase 1 (cdk1 ⁄ Cdc2) controlling the checkpointbetween...

Báo cáo khoa học: Alternative splicing: global insights potx

... expression patterns of FOX1 and -2.Analysis of breast and ovarian cancer using an RT-PCR panel of alternative splicing events indicated thatone-third of cases of increased exon skipping in cancerwere ... cross-linking and immunoprecipitation; CELF, CUGBP and ETR3 like family (of RNA binding proteins); CUGBP, CUG bindingprotein; miRNA, micro-RNA; RNP, ribonucleoprotein; MBNL, muscleblind like; ... in future attempts to link factors with enrichedmotifs.NOVA and FOX maps In the case of two families of mammalian proteins, theFOX and NOVA proteins, a variety of techniques,culminating in...

Tài liệu Báo cáo khoa học: "An Empirical Investigation of Discounting in Cross-Domain Language Models" ppt

... subsampling is that we use our entire trainingcorpus, and in so doing compromise between min-imizing errors from data sparsity and accommodat-ing domain shifts to the extent possible.3 A Growing ... in- domain (NYT00+01) and out -of- domain (AFP02+05+06) training corpora, for two meth-ods of closing the vocabulary. in each to optimize tune-set perplexity.For evaluation, we train, tune, and ... closing of the vocabulary. Moore and Lewis (2010) achievelower perplexities, but they use in- domain trainingdata that we do not include in our setting.We brieﬂy highlight some interesting...

Tài liệu Báo cáo khoa học: "An Implemented Description of Japanese: The Lexeed Dictionary and the Hinoki Treebank" ppt

... glosses)grammar in tandem with the treebank, as part of our research into natural language understanding.Treebanking the output of the parser allows usto immediately identify problems in the grammar, and ... the use of similarity and/ or se-mantic class based back-offs for parsing and gen-eration with both symbolic grammars and statisti-cal models. In order to make the system self sustaining webase ... are currently tagging other genres withthe same information. We will then use this infor-mation and the thesaurus to build a parsing modelthat combines syntactic and semantic information.We...

Tài liệu Báo cáo khoa học: "Portable Translator Capable of Recognizing Characters on Signboard and Menu Captured by Built-in Camera" docx

... the beginning and ending of the character string to be recognized and translated. In Figure 3, circles on both ends of thestring denote the user speciﬁed points. All the lo-cations of characters ... contains many signboards whose phrasesprovide useful information. These include destina-tions and notices in transportation facilities, names of buildings and shops, explanations at sightseeingspots, ... delineated by rect-angles and have x,y coordinates (as shown in Fig-ure 2), the module considers all candidates and ratesthe arrangement of rectangles according to the dif-ferences in size and...

Tài liệu Báo cáo khoa học: "An Empirical Investigation of Proposals in Collaborative Dialogues" docx

... consists of 24 computer-mediated dialogues 1 in which two participants collaborate on a simple task of buying furniture for the living and dining rooms of a house (a variant of the task in (Walker, ... corpus, and the issue of tracking agreement. Next we describe our coding scheme and our intercoder reliability outcomes. Last we report our findings .on tracking agreement. 2 Tracking Agreement ... participants' main goal is to negotiate purchases; the items of highest priority are a sofa for the living room and a table and four chairs for the dining room. The problem solving task is complicated...

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