... Radiation Oncology and Biology, University of Oxford, UK3 Institute of Pathology, Bad Berka, Germany4 National University of Ireland, Department of Biochemistry, Galway, Ireland5 Center for ... 3669initiation and elongation steps of DNA replication[12–14]. Chromatin association of Cdc45 requiresactivity of both cyclin-dependent kinases and Cdc7[15,16]. Studies in baker’s yeast and Drosophilarevealed ... observed consecutiveexpression of Cdc6, Cdc45 and polymerase a (Fig. 5C)ABFig. 9. Immunohistochemical detection of human Cdc45, PCNA and Ki-67. The proteins Cdc45, Ki-67 and PCNA were detected in...