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Tài liệu Báo cáo khoa học: "THERE STILL IS GOLD IN THE DATABASE MINE" potx

Tài liệu Báo cáo khoa học:

Tài liệu Báo cáo khoa học: "THERE STILL IS GOLD IN THE DATABASE MINE" potx

... THERE STILL IS GOLD IN THE DATABASE MINE Madeleine Bates BBN Laboratories 10 Moulton Street Cambridge, MA 02238 Let me state clearly at the outset that I disagree with the premise that ... databasesl" has resulted in this panel, which is supposed to debate the necessity of continuing work in this area rather than to debate technical issues in the area. And yet if this problem has been ... interfaces (limiting that phrase, for the moment, to mean typed English sentences) to various kinds of information systems. At one end of this spectrum is simple, single database query, in...
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Tài liệu Báo cáo khoa học: Interruption of triacylglycerol synthesis in the endoplasmic reticulum is the initiating event for saturated fatty acid-induced lipotoxicity in liver cells pdf

Tài liệu Báo cáo khoa học: Interruption of triacylglycerol synthesis in the endoplasmic reticulum is the initiating event for saturated fatty acid-induced lipotoxicity in liver cells pdf

... synthesiswas initially hindered following stearate administrationand was completely interrupted at longer incubationperiods. Interestingly, the interruption of TAG synthe-sis preceded the ... thusexcluding the possibility of nonspecific inhibition ofER stress. When the available acyl-CoAs are in excess,they are channeled towards TAG synthesis. The main findings of the present investigation ... the TAG pool only in the presence of oleate [18]. The above results raise two main questions: (a) what is the cause of TAG synthesis inhibition, and (b) what is the exact nature of the events that...
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Tài liệu Báo cáo khoa học: Domain deletions and substitutions in the modular protein evolution doc

Tài liệu Báo cáo khoa học: Domain deletions and substitutions in the modular protein evolution doc

... combinations are the P-loopnucleotide triphosphate hydrolase domain, the epider-mal growth factor (EGF) domain, the SH3 domain, the P-kinase domain and the domains involved in the blood clotting ... domain deletions are more com-mon at either of the protein termini, and that theiroccurrence is slightly higher at one of the termini,depending on the number of domains in the proteinand the ... missing anywhere in the arrangement. Then we calculated the frequency of the deletion at each domain position within the group ofproteins containing a given number of domains.We found that the...
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Tài liệu Báo cáo khoa học: Tryptophan tryptophylquinone cofactor biogenesis in the aromatic amine dehydrogenase of Alcaligenes faecalis Cofactor assembly and catalytic properties of recombinant enzyme expressed in Paracoccus denitrificans pptx

Tài liệu Báo cáo khoa học: Tryptophan tryptophylquinone cofactor biogenesis in the aromatic amine dehydrogenase of Alcaligenes faecalis Cofactor assembly and catalytic properties of recombinant enzyme expressed in Paracoccus denitrificans pptx

... carbinolamine intermediate;III, iminoquinone intermediate; IV, product Schiff base intermediate;V, aminoquinol intermediate. In the oxidative half-reaction the ami-noquinol intermediate is converted ... substrates. The lackof inhibition observed with benzylamine (Fig. 5A) in comparison to the inhibition observed with tryptamine(Fig. 5B) suggests differences in binding of the twosubstrates within the ... (orf-1 )in the aau gene cluster is not certain and it is not related tomauF, which is found at the corresponding position in the mau gene cluster [7]. The gene orf-2 in the aau genecluster is predicted...
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Tài liệu Báo cáo khoa học: Single phosphorylation of Tyr304 in the cytoplasmic tail of ephrin B2 confers high-affinity and bifunctional binding to both the SH2 domain of Grb4 and the PDZ domain of the PDZ-RGS3 protein ppt

Tài liệu Báo cáo khoa học: Single phosphorylation of Tyr304 in the cytoplasmic tail of ephrin B2 confers high-affinity and bifunctional binding to both the SH2 domain of Grb4 and the PDZ domain of the PDZ-RGS3 protein ppt

... determining the binding specificity towards phosphopeptides. For example, the b-sheet structure after the EF3 segment in the Src SH2does not exist in the Grb4 SH2 domain while the insertionafter the ... titration with the Grb4 SH2 domain, i.e. the binding isotherms (Fig. 4A). The ephrinB2(301–333)-pY304 peptide was found to have the strongest bindingto the Grb4 SH2 domain while the other five peptides,ephrinB2(301–333), ... Thus, the conformation of the PDZ binding domain of eph-rinB2(301–333) is essentially independent of tyrosinephosphorylation within the SH2-binding element of eph-rinB2(301–333).On the other...
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Tài liệu Báo cáo khoa học: Human intrinsic factor expressed in the plant Arabidopsis thaliana doc

Tài liệu Báo cáo khoa học: Human intrinsic factor expressed in the plant Arabidopsis thaliana doc

... Aarhus, DenmarkIntrinsic factor (IF) is the gastric protein that promotes the intestinal uptake of vitamin B12. Gastric IF from animalsources is used in diagnostic tests and in vitamin pills.However, ... analytical andtherapeutic purposes.Keywords: arabidopsis; cobalamin; intrinsic factor; recom-binant.Vitamin B12(cobalamin, Cbl) is the most complex of the vitamins [1]; it is a complicated ... of the protein was cleaved at the internal site …PSNPflGPGP. The key properties of the preparation obtained were identical to those of native IF: the binding curves of vitamin B12to recombinant...
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Tài liệu Báo cáo khoa học: Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction pptx

Tài liệu Báo cáo khoa học: Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction pptx

... onabnormalities in microsomal drug-metabolizing func-tion during the late phase of sepsis [6]. However, the underlying mechanisms involved in hepatic dysfunctionduring sepsis remain elusive.Among ... this increase was attenuated byGdCl3.DiscussionSeveral studies have shown that interactions betweenKCs and endotoxin comprise the initiating event lead-ing to hepatotoxicity in liver injury, ... liver injury, including endotox-emia and ischemia ⁄ reperfusion injury [14]. In ourstudies, we employed GdCl3to inactivate KCs basedon the findings of other investigators showing the destruction...
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Tài liệu Báo cáo khoa học: Transient RNA–protein interactions in RNA folding docx

Tài liệu Báo cáo khoa học: Transient RNA–protein interactions in RNA folding docx

... repulsive interactionswithin the RNA molecule. The protein therebysmooths the folding energy landscape. The direction of the RNA folding reaction (either annealing or dis-placement) is then no ... annealing of the new duplex finally results in either the replacement of the original strand or the expulsion of the invadingstrand, according to the kinetics and thermodynamicsituation. If the ... represent the flexibleresidues within the protein domain. NMR dataprovide evidence that the interaction site on the RNA is the phosphate backbone. This is also in accordancewith the demonstrated inhibitory...
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Tài liệu Báo cáo khoa học: A systems biology approach for the analysis of carbohydrate dynamics during acclimation to low temperature in Arabidopsis thaliana doc

Tài liệu Báo cáo khoa học: A systems biology approach for the analysis of carbohydrate dynamics during acclimation to low temperature in Arabidopsis thaliana doc

... perhour. Data points were spline-interpolated to obtain time-continuous information on net photosynthesis during the whole period of cold exposure. The rate of raffinose synthe-sis, rSuc fi Raf, ... successful metabolic engineeringof freezing tolerance in plants should include such ananalysis of the dynamics of metabolism to gain com-prehensive information about the effects of individualoverexpression ... to engineer plant metabolism in order to improvefreezing tolerance, one could suggest increasing the maximum activities of enzymes participating in sucrosecycling. Assuming that Rsch is optimized...
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Tài liệu Báo cáo khoa học: Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1 docx

Tài liệu Báo cáo khoa học: Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1 docx

... hypoxanthine and guanine is only 0.26% and0.09%, respectively, of the activity of HPRT, the roleof the PRTFDC1 in purine metabolism remainsunclear and it is uncertain whether it has the capacityto ... asfor HPRT. The DSLS results also suggest a sequentialmechanism where PRPP binds first, inducing a confor-mation change, then allowing the purine base to bind in accordance with the mechanism of ... differences in catalytic efficiency could beexplained by the difference in amino acid residuesinvolved in catalysis between PRTFDC1 and HPRT. In the structure, residues interacting with PRPP in PRTFDC1...
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