... Norwegian Structural Biology Centre, Faculty of Science, University of Tromsø, Norway2 Department of Molecular Biotechnology, Faculty of Medicine, University of Tromsø, NorwayThe marine and estuarine ... concentrations of NaCl. The periplasmic or extra-cellular localization of the enzymes, which renders them constantly exposedto the outer environment of the cell, may explain this fine-tuning of bio-chemical ... enzyme must sacrificesome of its stability. It has previously been suggestedthat the lower thermal stability of cold-adaptedenzymes is simply a consequence of the lack of select-ive pressure...