... (tetrabutylammonium),cyclic aliphatic (1-methylpyrrolidine; N,N-dimethyl-cyclohexylamine) or aromatic [2,4,6-tris(dimethyl-aminoethyl)phenol] chains, that might in principlebetter fill the hydrophobic binding ... occupation of high-affinity binding sites by cholinetriggers the dimerization of C-LytA [21]. The effect of bicyclic amines on C-LytA oligomerization was ana-lyzed by size-exclusion chromatography. ... on the enzymatic activity of full-length choline-binding murein hydrolases. Figure 5A–C shows theinhibitory effect of choline, atropine, and ipratropiumon the activity of LytA, LytC and Pce,...