Tài liệu The Conquest of the Old Southwest: The Romantic Story of the Early Pioneers into Virginia, The Carolinas, Tennessee, and Kentucky 1740-1790 pot
Tài liệu The Conquest of the Old Southwest: The Romantic Story of the Early Pioneers into Virginia, The Carolinas, Tennessee, and Kentucky 1740-1790 pot
... of North Carolina made a tour of explorationCHAPTER IV. 19 The Conquest of the Old Southwest: The Romantic Story of the Early Pioneers into Virginia, The Carolinas, Tennessee, and Kentucky 1740-1790, ... #2390]Project Gutenberg Etext, The Conquest of the Old Southwest: The Romantic Story of the Early Pioneers into Virginia, The Carolinas, Tennessee, and Kentucky 1740-1790, by Archibald Henderson ******This ... fertility of the land, the healthy temperature of the air and the mildness of the climate, the plenty of hunting, fishing and fowling, the facility of trade with the Indians and the vast convenience of...
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Tài liệu Commodore Barney''''s Young Spies A Boy''''s Story of the Burning of the City of Washington docx
... 1812."As a matter of course, we of the rank and file knew very little concerning the trials of the officer who wascharged with the defense of the city; but we did understand that our force ... day, and many of them to the cold dews of the night, uncovered. They have inthis period drawn but two rations, the requisition therefor in the first instance being but partially compliedwith, and ... The people of the flotilla, under the orders of Barney, and the marines, werejustly applauded for their excellent conduct. No troops could have stood better, and the fire of both artilleryand...
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Tài liệu Báo cáo khoa học: Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen pdf
... on the other hand betweenGRASP55 and furin led us to hypothesize thatGRASP55 could potentially play a role in the forma-tion of a complex between MT1-MMP and furin. Totest this hypothesis, ... modifications of the MT1-MMP ICD have also been reported with the palmitoy-lation of the cysteine 574 (C574) residue [30] and the phosphorylation of the tyrosine 573 (Y573) [31] and threonine ... Interestingly,mutation of the LLY573motif led to the detection of pro-MT1-MMP in the immunoprecipitate, sugges-ting that the disruption of the interaction betweenMT1-MMP and GRASP55 could affect the activationof...
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Tài liệu Báo cáo khoa học: Phylogenetic relationships in class I of the superfamily of bacterial, fungal, and plant peroxidases pptx
... discrepancybetween the rather high GC c ontent o f p roteobacterialKatGs a nd the GC content of the whole o rganism(Table 2), s upporting the hypothesis on the direction of the lateral gene transfer. ... [12], and thus the role of the corresponding part of the gene is alsounknown. These g ene f usions togeth er with single-copygenes of APXs and CCPs are ideal for investigating the evolution of ... copies of the primordial peroxidase gene [5,15]. The copy trans-lated into the N-terminal domain participates in catalysis and possesses t he prosthetic heme group, but the c atalyticfunction of the...
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Tài liệu Báo cáo khoa học: Evidence for interactions between domains of TatA and TatB from mutagenesis of the TatABC subunits of the twin-arginine translocase docx
... analyzed the effects of substituting groups of basic residues inthese regions of TatA and TatB [24]. The present studyhas increased our understanding of this region in twoways. First, the removal of ... in the presence of substrate and a protonmotive force [23]. On the basis of these studies, it hasbeen proposed that binding of substrate to the TatBCsubunits triggers the recruitment of the ... parallel with the Sec system, it is responsible for the export of a subset of proteins into the periplasm, outer membrane orextracellular medium, and the primary defining attrib-ute of the system...
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Tài liệu Báo cáo khoa học: A single amino acid substitution of Leu130Ile in snake DNases I contributes to the acquisition of thermal stability A clue to the molecular evolutionary mechanism from cold-blooded to warm-blooded vertebrates docx
... not. The same was true for these mutants of the rat and mouseDNase I (Fig. 3). These findings demonstrate that the nature of the amino acid at position 130 may generally and markedly affect the thermal ... closeto mammalian and avian DNases I.Thermal stabilities of wild-type and substitutionmutant snake DNases I The thermal stabilities of the wild-type and mutantenzymes of the snakes were examined ... cell turnover and thus for the prevention of systemic lupus erythematosus (SLE) [12]. The gene product of human DNASE1*6 was morethermally unstable than that of the other alleles and subjects...
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Tài liệu Báo cáo khoa học: Different mechanisms for cellular internalization of the HIV-1 Tat-derived cell penetrating peptide and recombinant proteins fused to Tat docx
... treatmentabolished the internalization of the GFP-fused Tat proteinbut did not alter the uptake of the Tat CPP. Thesebiochemical evidences con®rmed a pathway for the e ntry of the Tat peptide unrelated to the ... at the level of membrane structu res implicated in the T at peptide uptake i sunder evaluation.Comparative FACS analysis of the internalization of the full-length Tat protein construct and the ... routes for the Tat CPP and the Tat protein.What might be the reasons underlying the observeddifferences in cellular uptake between the Tat CPP and the GST±Tat±GFP protein, that both contain the same...
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Tài liệu Báo cáo Y học: A Raman optical activity study of rheomorphism in caseins, synucleins and tau New insight into the structure and behaviour of natively unfolded proteins pot
... longer-chain (and nonglobular) versions of the structure of the Bowman±Birk inhibitor in Fig. 6 . The X-ray crystal structure 1 pi2 reveals that the /,w angles of most of the residues of the Bowman±Birk ... orm of b strand [18]. The positive bands at » 1675 cm)1in the amide I r egion of the ROA spectra of b-andj-casein, which originate mainlyin the peptide C O stretch, are characteristic of ... of the soybean variant of thisprotein, together with its ROA spectrum measured earlier[19]. The general appearance of the ROA spectrum is quitesimilar to those of the caseins, synucleins and...
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Tài liệu Báo cáo Y học: Enhancement by a-tocopheryl hemisuccinate of nitric oxide production induced by lypopolysaccharide and interferon-c through the upregulation of protein kinase C in rat vascular smooth muscle cells docx
... degrees of inhibition of NO production with Ro31-2880 and GF109203X were approximately 70 and 30%, respectively.Effects of TS on the amount of PKCaWe further examined the effects of TS on the amounts ... induced the NO productions butwere very feeble as 1.1-fold and 1.4-fold of control,respectively. These results indicate that the detectablehigh NO production needs the presence of both LPS and IFN ... inhibitedby the coexistence of a-T, TA and TN (Figs 3 and 4), butnot of the antioxidants BHA and AsA. These resultssuggested that active oxygens and free radicals did notparticipate in the TS effect,...
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