... conformation, the SH2 domain binds to pYion the C-terminal tail, and the Src homology 3 (SH3) domain binds to the linkerbetween the SH2 and kinase domains at the back of the small lobe, preventing the ... by presenting the pulse of Src activity in the plane of the inactive and active fractions, siand s1. If the duration of the stimulus exceeds the critical value, the trajectory in the (si, ... RTKs, can bind the Src SH2 domain, facilitatingdephosphorylation of the inhibitory tyrosine pYi. The phosphatases that dephosphorylate the activating sitepYainclude the C-terminal site phosphatases,...