Tài liệu Báo cáo khoa học: Infrared spectroscopy as a tool for discrimination between sensitive and multiresistant K562 cells doc

... Infrared spectroscopy as a tool for discrimination between sensitive and multiresistant K562 cells Anthoula Gaigneaux, Jean-Marie Ruysschaert and Erik GoormaghtighLaboratory of Structure and ... infrar ed spectroscopy for c lassification.Further analysis o f t he spectral differences indicated that discrimination between r esistant and sensitive cells wasbased o n variations in all cellular ... thebiochemical information available i n infrared s pectra, and we found that infrared spectra of resistant K562 cells aresignificantly modified relative t o their sensitive counterpartat all molecular...

Tài liệu Báo cáo khoa học: Phage-display as a tool for quantifying protein stability determinants pptx

... the association of the variable heavy chain (VH)withprotein A was used as a surrogate for direct stabilitymeasurements. The VHdomains in camelid heavy chainantibodies are most similar to ... stabilities. Remarkably, wehave found that, at least in some circumstances, a quanti-tative correlation to biophysical data can be obtained from a statistical analysis of selected phage populations ... residues near the Fcbinding interface cannot be varied (for instance, coreresidues 3 and 39, and boundary residues 25 and 29 thatwere all changed in a hyperstable GB1 variant [12]). Basedon...

Tài liệu Báo cáo khoa học: Control analysis as a tool to understand the formation of the las operon in Lactococcus lactis doc

... CP-pyk(5¢-ACGACTAGTGGATCCATNNNNNAGTTTATTCTTGACANNNNNNNNNNNNNNTGRTATAATNNNNAAGTAATAAAATATTCGGAGGAATTTTGAAATGAATAAACGTGTAAAAATCG-3¢)(N¼ A, T, G, C) and pyk-back (5¢-CTCTACATGCATTTCAACAATAGGGCCTGTC-3¢) for amplification of pyk. The resulting ... (5¢-GGAAGGATCCTTGTGTTTTTCTCCTATAATG-3¢) and downstream to pyk using primer pyk3 (5¢-GGAAGGATCCTTTGTCAATTAATGATCTTAAAAC-3¢) and pyk4(5¢-CTAGTCTAGATGAGCTCCAGAAGCTTCC-3¢) wereamplified. The PCR products ... À a lasÞÃð1 À eÀ6 a 2:1lasÞÀ33:2 (User defined),Jlactate a lasÞ¼0:919 Ãð129 À a lasÞÃð1 À eÀ6 a 2:1lasÞÀ75:2 (Us erdefined), Jacetate a lasÞ¼0:1135 ÃðÀ30:3 À a lasÞÃð1 À eÀ6 a 3:3lasÞþ4:66...

Tài liệu Báo cáo khoa học: "Finite Structure Query: A Tool for Querying Syntactically Annotated Corpora" doc

... (Ci),(M,),(F,))) be a tree, and X be a set of variables. A variable assignment a : X N is a function thatassigns a node from N to each variable. Let a be a variable assignment. The truth ... cate-gories as node labels, grammatical functions as edge labels and dependency relations. The syn-tactic categories follow traditional phrase struc-ture and the theory of topological fields. An ex-ample ... Universallyquantified formulae are evaluated similarly. Theevaluation of a boolean connective is a straightfor-ward recursion. In the case of a conjunction, e.g.,each conjunct is evaluated separately...

Tài liệu Báo cáo khoa học: "Text Alignment in a Tool for Translating Revised Documents" docx

... Introduction Making use of previously translated texts is a very appealing idea that can be of considerable prac- tical and economical benefit as a translation aid. There are different ways to exploit ... Nationalization Situations where a document needs re-translation are usually associated with commercial products that undergo modifications and revisions and require ac- companying literature ... they happen, can only have a very local effect. To demonstrate this, let us con- sider a concrete example. An English and a French versions of a software manual contain 628 and 640 paragraphs,...

Tài liệu Báo cáo khoa học: Angiopoietin-like proteins: emerging targets for treatment of obesity and related metabolic diseases pptx

... of ANGPTL2 signaling as a therapeu-tic strategy is more beneficial.Because ANGPTL2 promotes vascular inflammationvia the a5 b1 integrin ⁄ Rac1 ⁄ NF-jB pathway [15] and vascular injury accompanied ... maybe a mediator linking smoking to cardiovasculardisease in an autocrine or paracrine manner. BlockingANGPTL2 signaling may also be beneficial alsoin preventing and treating cardiovascular ... Y, Akao M, Yasunaga K, Yamauchi T, MorisadaT, Ito Y, Urano T, Kimura Y, Kubota Y, Maekawa Het al. (2005) Angiopoietin-related growth factor antago-nizes obesity and insulin resistance. Nat...

Tài liệu Báo cáo khoa học: Pharmacologic chaperoning as a strategy to treat Gaucher disease ppt

... tolm) and stabilize just one protein and thus are gener-ally protein and disease selective, if not speciﬁc.Many of the clinically important Fabry disease-asso-ciated a- galactosidase A variants ... S, Asano N & Suzuki Y (1999) Acceler-ated transport and maturation of lysosomal alpha-galac-tosidase A in Fabry lymphoblasts by an enzymeinhibitor. Nat Med 5, 112–115.20 Fan J-Q & ... a- galactosidase A residual activity inpatient derived cells; thus, galactose was demonstratedto be ﬁrst active-site-directed pharmacologic chaperone for a lysosomal storage disease. Galactose administra-tion...

Tài liệu Báo cáo khoa học: Expression of an a-1,3-glucanase during mycoparasitic interaction of Trichoderma asperellum docx

... a- 1,3-glucanase;mycoparasitism; Trichoderma asperellumCorrespondenceE. Monte, Centro Hispano Luso deInvestigaciones Agrarias, Universidad deSalamanca, Ediﬁcio Departamental, PlazaDoctores de la ... Trichoderma vs. Botrytis confron-tation in plate assay (2) and during Trichoderma vs. Trichoderma confrontation in plate assay (3).Mycoparasitic a- 1,3-glucanase from T. asperellum L. Sanz et al.496 ... of an a- 1,3-glucanase (EC 3.2.1.59, enzymes able to degrade a- 1,3-glucans and also named mutanases) has been described in T. harzia-num and its role in mycoparasitic processes has been suggested....

Tài liệu Báo cáo khoa học: "Sentence generation as a planning problem" pptx

... be false. Actions have a number of param-eters, as well as a precondition and effect, both ofwhich are logical formulas. When a planner tries toapply an action, it will ﬁrst create an action ... withoutbeing changed by the action. Atoms are printed inboldface iff they contradict the goal.This plan can be read as a derivation tree that hasone node for each action instance in the plan, and anedge ... communicative goals as ﬂaws that the plan must remedy. To this end,we add an atom cg(P ,a 1, ,a n) for each elementP (a 1, ,a n) of the communicative goal to the ini-tial state, and we add a corresponding...

Tài liệu Báo cáo khoa học: "Seeing stars: Exploiting class relationships for sentiment categorization with respect to rating scales" doc

... 30%Table 2: Average over authors and class pairs of between- class vocabulary overlap as the class labelsof the pair grow farther apart.shows that in aggregate, the vocabularies of distantclasses ... examples for one author are:“meaningless”, “disgusting” (class 0); “pleasant”,“uneven” (class 1); and “oscar”, “gem” (class 2) for the three-class case, and, in the four-class case,“flat”, “tedious” ... we can also incorporate class relationsby directly altering the output of a binary classifier, as follows. We first train a standard SVM, treatingratings greater than 0.5 as positive labels and...

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