Tài liệu Báo cáo khoa học: Regulatory modes of rod outer segment membrane guanylate cyclase differ in catalytic efﬁciency and Ca2+-sensitivity ppt

... Regulatory modes of rod outer segment membrane guanylate cyclase differ in catalytic efﬁciency and Ca2+-sensitivityJi-Young Hwang1,*, Christian Lange1,†, Andreas Helten1, ... bovine and amphibian rod outer segments [6–9], and it is the only cyclase which has beencloned based on its amino acid sequence [8,10]. Humanretinal diseases (LCA1 and CORD6) affect both rod and cone ... theamount of cyclase in ROS was obtained directly from thecalibration curve. The predominant membrane guanylate cyclase in bovine ROS is ROS-GC1, the other isoform(ROS-GC2) that is expressed in photoreceptor...

Tài liệu Báo cáo khoa học: Different modes of dipeptidyl peptidase IV (CD26) inhibition by oligopeptides derived from the N-terminus of HIV-1 Tat indicate at least two inhibitor binding sites doc

... N-terminus (Met1) of Tat(1–9) and Asp709 as well as Asp739 of DP IV, between the C-terminalGlu9 of Tat(1–9) and the side chains of Arg560 and Lys554 of DP IV. Furthermore, the side chain of Asp5 of ... suitable forthe determination of the Kivalue. From the Hill-plot, binding of the inhibitor to different binding sites was reﬂected by thechange of the slope in dependence of the inhibitor concen-tration. ... enzyme functions as abinding molecule for adenosine deaminase [12]. TheDP IV-catalyzed hydrolysis of the N-terminus of differentchemokines resulting in changed receptor binding potentialsreﬂects...

Tài liệu Báo cáo khoa học: The stereochemistry of benzo[a]pyrene-2¢-deoxyguanosine adducts affects DNA methylation by SssI and HhaI DNA methyltransferases pptx

... CGM and GCX+⁄ CGM), 5-methylcytosine was introducedinto one of the strands of the recognition site instead of the target cytosine. The melting curves of the hemi-methylated X+CG ⁄ CGM and ... DNA and AdoHcy(AdoMet) [44], M.HhaIconsists of two domains, the large domain containingthe S-adenosyl-l-methionine (AdoMet) binding site and the catalytic center, and the small domain contain-ing ... intercalativeconformation of the (+)-cis adduct and the minor-groove conformation of the (+)-trans adduct, the lat-ter interfering with interactions of the catalytic loops of the MTases and the minor groove of DNA....

Tài liệu Báo cáo khoa học: The localization of FGFR3 mutations causing thanatophoric dysplasia type I differentially affects phosphorylation, processing and ubiquitylation of the receptor pptx

... staining of 293-VnR and ATDC5 cells expressing the Y373C mutant with anti-FGFR3 and anti-phosphotyrosine sera showed bothintracellular and cell-surface phosphotyrosine staining(Figs 2Eb,c and ... 70Z-Cbl (a mutant lacking 17 amino acids in the linker and RING ﬁnger domain of c-Cbl) and wild-type or mutantFGFR3 cDNAs as indicated, then immunoprecipitated and blotted as in (B).J. Bonaventure ... Conversion of Lys650 into methionine in the TK2 domain induceshyperphosphorylation and marked intracellular retent-ion of the mutant receptor leading to phosphorylation of target signalling molecules...

Tài liệu Báo cáo khoa học: Quantitative estimation of channeling from early glycolytic intermediates to CO2 in intact Escherichia coli pdf

... channelingPrior investigations of channeling may be divided intotwo categories: in vitro and in vivo. The former includeexperiments with cell extracts and puriﬁed enzymes.These are inherently ... and 3H-labeled protein were measured. The3Hinprotein was insigniﬁcant, showing that the aminoacyl-tRNA made from amino acids and tRNA did not mixwith the introduced aminoacyl-tRNA; i.e. there ... inherently unsatisfying. In particular, chan-neling is thought to be the result of protein–proteininteractions in the crowded, organized environment of the cell. Although investigators sometimes...

Tài liệu Báo cáo khoa học: "An ERP-based Brain-Computer Interface for text entry using Rapid Serial Visual Presentation and Language Modeling" ppt

... channels.The RSVP interface is of particular utility for themost impaired users, including those suffering fromlocked -in syndrome (LIS). Locked -in syndrome canresult from traumatic brain injury, such ... seen in the timing diagram shown in Figure 5, epoch k contains between 1 and Mksequences. This ﬁgure shows the onset of each se-quence, each ﬁxation image (which is shown at thebeginning of ... inconvenient, such as in face-to-face communication. Auditory scanning isless straightforward when using a grid. Second,multi-character substrings can be scanned in RSVP,whereas the kind of...

Tài liệu Báo cáo khoa học: Functional dissection of the Schizosaccharomyces pombe Holliday junction resolvase Ydc2: in vivo role in mitochondrial DNA maintenance pptx

... study of the role of recombination in mtDNA inheritance in S. cerevisiae showed that buddingcells were enriched in linear monomers of mtDNA. It wasproposed that in addition to a role in initiating ... species.The role of Ydc2 for maintaining the content of mtDNA in ﬁssion yeast is not clear. Apart from DNA repair,recombination could be involved in the initiation of mtDNA replication (recombination-dependent ... junctions in mtDNA fromhuman heart muscle was recently demonstrated [38]suggesting that recombination intermediates and enzymesthat resolve them could be involved in maintaining thestability and inheritance...

Tài liệu Báo cáo khoa học: Crystal structures of the regulatory subunit of Thr-sensitive aspartate kinase fromThermus thermophilus pdf

... insertedinto the ACT2 domain; and (c) two ACT domains,each from a different chain, interact to form an effec-tor-binding unit. The effector-binding unit of theACT domain in the b-subunit of CgAK ... 53–59 in chain B, residues 55–56 in chain C, residues 56–57 in chain E, and residues 53–56 in chain F) of the loopbetween b3 and b4 are not observed in every chain.The overall geometry of the ... change of the regulatory domaindimer upon Lys binding, resulting in the displacement of several residues responsible for catalytic function in the catalytic domain. The most distinct differencebetween...

Tài liệu Báo cáo khoa học: Elementary modes analysis of photosynthate metabolism in the chloroplast stroma ppt

... as being somecombination of the following: (a) production of redoxpotential in the form of NADPH; (b) production of glycolytic intermediates, reducing the demand put uponphosphofructokinase; ... be deﬁned in terms of modes thus: a mode of a system is a set of reactionswhose net stoichiometry (i.e. in terms of externalsubstrates and products) is balanced and within whichall internal ... sedoheptulose-1,7-bisphosphatase.DiscussionOne of the original goals motivating this structural inves-tigation of the Calvin cycle was to determine whether or notthe traditional reactions of the Calvin cycle are capable of sustaining...

Tài liệu Báo cáo khoa học: Molecular basis of glyphosate resistance – different approaches through protein engineering doc

... accompanied by improved bind-ing to longer ligands (up to ﬁve atoms in the mainchain) and retained binding to shorter ligands [55]. Of the 21 changes in the evolution of R7 fromnative GLYAT ... thermo-stability and protein expression in E. coli determined for wild-type GO and variants of GO obtained by site-saturation mutagenesis of thepositions identiﬁed by docking analysis or by introducing multiple ... distinctive protein fold and the large conformational changes that occur uponsubstrate binding and catalysis [16,19,20].Discovery and engineering of glyphosate-resistantEPSPSThe extraordinary...

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