Tài liệu Báo cáo khoa học: Role of cleavage and shedding in human thyrotropin receptor function and trafficking pdf
Tài liệu Báo cáo khoa học: Role of cleavage and shedding in human thyrotropin receptor function and trafficking pdf
... 3497 Role of cleavage and shedding in human thyrotropin receptor function and trafficking Myle`ne Quellari1, Agne`s Desroches1, Isabelle Beau1, Emmanuelle Beaudeux1 and Micheline Misrahi1,21INSERM ... cleavage and shedding on the one hand, and the receptor activated by the ligand on the other hand. Cleavage and shedding of a receptor already activated by a transmem-brane activating mutation ... isinvolved in the shedding of human thyrotropin receptor ecto-domain. Biochemistry 35, 14800–14805.13. Latif, R., Graves, P. & Davies, T.F. (2001) Oligomerization of the human thyrotropin...
- 12
- 538
- 0
Tài liệu Báo cáo khoa học: Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction pptx
... shown that interactions betweenKCs and endotoxin comprise the initiating event lead-ing to hepatotoxicity in liver injury, including endotox-emia and ischemia ⁄ reperfusion injury [14]. In ourstudies, ... con-centrations of tumor necrosis factor-a and interleukin-6, and increasedhepatic mRNA levels of tumor necrosis factor-a and interleukin-6 weredecreased by depletion of KCs. Our findings suggest ... mediator of lethal sepsis, triggering theproduction of proinflammatory cytokines and liverinjury [13].Therefore, the present study aimed to elucidate the role of KCs in the regulation of CYP isoform...
- 11
- 769
- 0
Tài liệu Báo cáo khoa học: Role of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis pptx
... have indi-cated that the CagAPY-induced cell elongation pheno-type also involves tyrosine dephosphorylation of cortactin, vinculin and ezrin, which are three well-known actin-binding proteins ... the amount of intracellu-lar CagAPY. Cortactin, ezrin and vinculin are all Srcsubstrates, and Src inactivation causes dephosphoryla-tion of these proteins and is crucial for triggering cellelongation ... of bacteria gain access to integrins and inject CagA. Thebasal injection model of CagA can also explain whyH. pylori does not cause more gastric damage in infected individuals and may only inject...
- 13
- 866
- 0
Tài liệu Báo cáo khoa học: Role of ceramide kinase in peroxisome proliferatoractivated receptor beta-induced cell survival of mouse keratinocytes ppt
... Westrick RJ & GinsburgD (1998) Comparative mapping of distal murine chro-mosome 11 and human 17q21.3 in a region containinga modifying locus for murine plasma von Willebrandfactor level. ... acting as a ligand-inducible transcriptionfactor and has been implicated in the control of keratinocyte survival. In the mouse keratinocyte cell line SP1, serum starvation induced cell death and ... betweenCerK and PPARb, and its role in regulating keratino-cyte survival. We report that in a mouse keratinocytecell line upregulation of CERK expression by activa-tion of PPARb results in a decrease...
- 12
- 698
- 0
Tài liệu Báo cáo khoa học: Role of receptor-mediated endocytosis, endosomal acidification and cathepsin D in cholera toxin cytotoxicity pdf
... preparedfrom CT and CT-B-injected rats (Fig. 3A). An increase in ARF content was observed in endosomal fractionsisolated 5 min postinjection of CT-B, and this increasewas maintained for up to 60 min (Fig. ... cathepsin D inhibitor pepstatin Apartially inhibited, both in vivo and in vitro, the cAMP response to choleratoxin. This cathepsin D-dependent action of cholera toxin under the con-trol of endosomal ... compartmentalization and cytotoxic action of cholera toxin in rat liver parenchyma. Following administration of a saturating dose of cholera toxin to rats, rapid endocytosis of both cholera toxin subunits...
- 16
- 536
- 0
Tài liệu Báo cáo khoa học: Role of transcription factor activator protein 1 (AP1) in epidermal growth factor-mediated protection against apoptosis induced by a DNA-damaging agent doc
... and cell survival. They bind and activate a specific tyrosine kinase receptor that iscoupled to multiple intracellular signaling pathways[17,18]. Activation of tyrosine kinase receptors isinvolved ... transcription, were increased in response toEGF. Pretreatment of the cells with PD98059, an inhibitor of MAP kinasekinase, inhibited the EGF-induced c-Fos and c-Jun expression, AP1 DNAbinding, Bcl-XLexpression, ... vector by using Lipofectamine (Invitrogen).Cells were selected in neomycin, and clones were isolated and screened for Bcl-XLexpression.Creation of TAM67-overexpressing cell lineThe dominant-negative...
- 13
- 493
- 0
Tài liệu Báo cáo khoa học: Role of K22 and R120 in the covalent binding of the antibiotic fosfomycin and the substrate-induced conformational change in UDP-N-acetylglucosamine enol pyruvyl transferase docx
... charged amino acid sidechains, R397 and R120, are also involved in fosfomycinbinding, and in view of the multitude of interactions, it wasassumed that deletion of a single interaction would not ... chain of K22 participates in fosfomycin binding, thus providing a rationale for the loss of fosfomycin binding to the K22V and K22E mutant proteins.However, two other positively charged amino ... Hence, themechanism of binding of fosfomycin by reinforcement of aninitial binding site (mainly K22 and R397) through recruit-ment of secondary binding partners located in a flexibleloop (R120)...
- 9
- 707
- 0
Tài liệu Báo cáo khoa học: Role of hydroxyl group and R/S configuration of isostere in binding properties of HIV-1 protease inhibitors docx
... onconformation of inhibitor main chain. Thus, differentinhibitors differ not only in t he binding affinity, bu t a lso in the degree o f freedom of the inhibitor inside the bindingtunnel. Some s pecial inhibitors ... that t he strain imposed on inhibitor duringdocking into the binding site of pr otease does not allowcorrect orientation of the hydroxyl group to catalyticaspartates either in S or in the R configuration. ... of inhibitors OE, RE and SE towards their HIV-1 proteases. Stated numbers are distancesbetween inhibitor and protease atoms in A˚.Reside of Atoms of Inhibitor complexInhibitor Protease Inhibitor...
- 11
- 615
- 0
Tài liệu Báo cáo khoa học: Roles of heat shock factors in gametogenesis and development pptx
... section and scheme of the coronal section at E14.5 in (F). (A) At E11.5, HSF2 is expressed in forebrain, midbrain and in hindbrain except for the midbrain, hindbrain midline. Surprisingly, the ... would enhance or diminish the impact of HSF2 deficiency.Pending questions for the roles of HSF1 and HSF2 in oogenesis and in early embryosThe role of HSF2 in oogenesis and in pre-implantationdevelopment ... and inclusion-likestructures, which possibly exist in protein aggregatesbecause they contain aB-crystallin. More than 90% of the lens protein is composed of a variety of crystallins; Role of...
- 23
- 796
- 0
Tài liệu Báo cáo khoa học: Destabilization of psychrotrophic RNase HI in a localized fashion as revealed by mutational and X-ray crystallographic analyses pdf
... side-chains of K89, residue 90 and residue 97 are shown. The dis-tances between the e-amino groups of K89 and K90, and between the e-amino group of K90 and the guanidino group of R97, in the ... because of the intrinsic flexibility of theloop containing His124 and the crystal packing effect.Destabilization mechanism of So-RNase HIA combination of the six thermostabilizing mutationsincreases ... (B), the side-chains of residues 29, T34 and E131 are shown. The hydrogen bonds betweenN29 and Oc and T34 and Oc, and between N29 and Nd and E131 and Oe2, in the wild-type protein are shown as...
- 11
- 648
- 0
Từ khóa: Nghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpMột số giải pháp nâng cao chất lượng streaming thích ứng video trên nền giao thức HTTPđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitPhát hiện xâm nhập dựa trên thuật toán k meansNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngTìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinChuong 2 nhận dạng rui roTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)Kiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)Tăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtĐổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namMÔN TRUYỀN THÔNG MARKETING TÍCH HỢPTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲ