... Follistatin, Chordin and Noggin[12]. These proteins are antagonists of BMP and othermembers of the TGF-b family, binding to and inhibit-ing these signaling molecules from binding to theirreceptors ... theirreceptors in the extracellular space, thus inhibiting ven-tralizing activities. Of these proteins, Chordin has along-range effect. In Xenopus, expression of the chordingene is localized to the dorsal ... rescued.Expression of chordin is induced by Sizzled in embryoswith Chordin, but not in the absence of Chordin.These results indicate that Chordin is required for dor-salization through Sizzled.Recently,...