... organizationRoles of the Las17p (yeast WASP)-binding domain and a novelC-terminal actin-binding domainThirumaran Thanabalu1,2, Rajamuthiah Rajmohan2, Lei Meng2, Gang Ren4,5, Parimala R. Vajjhala4and ... Imyosins can interact via an acidic tail (A) domain with the Arp2 ⁄ 3 complex like Las17p, but they lack anactin-monomer-binding WH2 domain, which in WASP-family proteins (including Las17p) ... role in actin filament assembly in the actin patch. Binding of the LBD to Las17p mayalso stimulate Las17p-dependent activation of the Arp2 ⁄ 3 complex. De novo actin filament assembly iscritical...