Tài liệu Báo cáo khoa học: Two novel variants of human medium chain acyl-CoA dehydrogenase (MCAD) K364R, a folding mutation, and R256T, a catalytic-site mutation resulting in a well-folded but totally inactive protein pptx
... Two novel variants of human medium chain acyl-CoA
dehydrogenase (MCAD)
K364R, a folding mutation, and R256T, a catalytic-site mutation
resulting in a well-folded but totally inactive protein
Linda ... normal
enzyme. Eur J Biochem 246, 548–556.
15 Ikeda Y, Okamura-Ikeda K & Tanaka K (1985) Purifi-
cation and characterization of sh...
... Some Novel Applications of Explanation-Based Learning to
Parsing Lexicalized Tree-Adjoining Grammars"
B.
Srinivas and Aravind
K. Joshi
Department of Computer and Information Science ... is a part of the language defined by the
grammar. Parsing new sentences amounts to find-
ing analogous explanations from the training sen-
tences. As a special case of EBL, Samue...
... spectroscopy.
The N-terminal domain of CA (NTD) and the C-ter-
minal domain of CA (CTD) are small, globular and
mainly helical. NTD contains a- helices 1–7 of CA, and
is connected by a flexible linker to CTD, ... The Gag subunits are radially extended, with
the N-terminal domain, MA, associated with the inner
layer of the viral membrane, and the remaining
domains forming the...
... devel-
opment of new antiviral drugs that are able to interact with CA and ⁄ or its
domains, hampering HIV-1 assembly and infection.
Abbreviations
CA, capsid protein of HIV-1 (p24); CAC1, a CTD-binding ... this value can be
explained because an entropy penalty must be paid
during folding of both the CAI peptide and a- helix 9
of CTD during formation of the peptide–
pro...
... participates in picolinic
acid (PA), quinolinic acid (QA) and NAD homeostasis. Indeed, the enzyme
stands at a branch point of the tryptophan to NAD pathway, and deter-
mines the final fate of the amino acid, ... of
cerebral malaria, and as an important tool in validat-
ing our proposal of hACMSD as a novel drug target
for the treatment of diabetes and to investigate...
... mothers
contains subfractions of 150-kDa IgG and 360-kDa sIgA
antibodies, which hydrolyze DNA, RNA, and ATP [25,35].
After separation of human milk proteins by SDS/PAGE
in a gel containing DNA, an in- gel ... only in half of 14 analyzed milk samples. A similar
situation was observed after separation of human milk
proteins in a gel containing RNA; again LF was sign...
... flights)that serve dinner" offers
any constraint on the class AIRCRAFT: in other words,
that being a particular type of aircraft and being used
by a flight that serves dinner are correlated in ...
its range. Since every flight in ATIS is on an airline,
AIRLINE -OF is a total relation, and AIRLINE is its
range, so a referential metonymy is clearly vacuous in...
... paradigmatic and syntag-
matic lexical constraints, leading to the simplifica-
tion of the generator's grammar and lexicon, and
enhancing portability. By retraining the statisti-
cal ... to an independent component of the final
sentence. Each individual word in an island specifies
a choice point in the search and causes the creation
of a state in the lattice;...
...
presumes a mechanism modelling human problem
solving abilities, including reasoning about other
agents and inferring their intentions. The system has
a model of the current situation and the ability ... computation by eliminating interpretations,
and reinterpreting others. The linguistic computation
constrains plan reasoning by providing the input; the
final interpretation...
... contextual features are straightfor-
ward to obtain—all we need is a concordance of
the candidate compound annotated with parts of
speech.
Table 6 shows various combinations of numeric
features, but ... Copestake and Lascarides,
1997). Each lexical rule takes a pair of nouns of
certain semantic type as input, and the output of
the rule is a compound noun whose semantic...