... Oxidative stress in the hippocampus after pilocarpine-
induced status epilepticus in Wistar rats
Rivelilson M. Freitas, Silva
ˆ
nia M. M. Vasconcelos, ... nitrite content were
increased after SE. Lipid peroxidation in the brain can
Fig. 1. Biochemical alterations in the hippocampus of adult rats
after pilocarpine-induced SE. Male rats (250–280 g, 2 ......
... residue in the zinc-
bound MshB structure (PDB code 1Q74) adopts a sim-
ilar strained conformation. On the other hand, in the
absence of a zinc ion in the active site, such as in the
structures of the ... loop in the active site (e.g. in substrate
recognition).
The a2 helices in the BcZBP and TT1542 structures
are rotated relative to each other around their
C-t...
... near the
N-terminal portion of the protein and is characterized
either by a conserved histidine (as in diphtheria toxin,
ART3 and the PARPs) or by a conserved arginine
(as in pertussis toxin, ... which include
the purinergic receptor P
2
X
7
, the defensins and the integrins. Intracellular
mono(ADP-ribosyl)ation modifies proteins that have roles in cell signalling
and metabol...
... cooperative inter-
actions have been detected during metal-ion binding,
positive for the binding of Zn
2+
to the M1 site, and
negative for the binding of the activating cations to the M3
site ... activity, in the
presence of a high Mg
2+
concentration, is probably due
to Mg
2+
binding to the zinc binding sites (M2 and M1).
It appears that in contrast to the binding of Zn
2...
... nucleolin ⁄ C23 in oxidative stress- induced apoptosis,
but whether nucleolin ⁄ C23 participates in Hsp70-medi-
ated protection against H
2
O
2
-induced apoptosis is not
clear. In the present investigation, ... from
neonatal Wistar rats (1–3 days after birth) were removed,
minced and trypsinized at 37 °C with gentle stirring in
D-Hanks buffer containing 0.1% trypsin (Gibco,...
... cascades, mitogen-activated protein kinase
kinase kinase 7 interacting protein 2 (TAK 1 binding
protein 2 ¼ TAB 2), as an IEG during hyperosmotic
stress in tilapia gill epithelium [26]. This gene is
transiently ... rapidly (within 2 h) induced by
hyperosmotic stress, indicating a role of this mitogen-
activated protein kinase kinase kinase 7 interacting
protein for osmosensory signal tra...
... stress [161], sug-
gesting that these proteins are involved in ER stress-
specific apoptosis.
ATF6 is also involved in the apoptotic process dur-
ing myogenesis. In differentiating myoblast, the ... UCH-L1
ubiquitinates unfolded proteins and might be involved
in ERAD [203]. These findings strongly suggest the
involvement of ER stress in Parkinson’s disease. In
addition,...
... would
be stressed using either the rules of the the language that it was
borrowed from or the rules of the language that it was borrowed into.
But neither the rules of Japanese nor the rules ...
32020103
The strength of these constraints will help make up for the fact that
the mapping from orthography to weight is usually underdetermined,
In terms of information theory...
... a conserved DNA-binding motif
known as the Doublesex- and Mab-3-related (DM)
domain. Being a noncanonical cysteine-rich DNA-
binding motif, this domain has two highly intertwined
finger structures ... at higher levels
in testes than ovaries.
The deep interest in Dmrt1 in the field of sex deter-
mination in fish came with the discovery of a dmrt1
homologue on the Y chromosome of...
... metal-binding site
at the interface of the two domains, which consists
of four side chains: two (His31 and His79) from the
N-terminal domain and two (Asp165 and His169) from
the C-terminal domain ... attributed to the Mn or Fe ions incorporated into
the enzyme as it accumulated in the E. coli cells. Indeed,
the activity of the apo-enzyme was significantly lower
than the m...