... for the first time, thattau interacts with Fyn -SH2. Proteins harbouring SH2 domains bind to phosphorylated tyrosines on their tar-get proteins, thereby coupling the activity of tyrosinekinases ... tau contains tyrosines that could be targetedby Fyn, and tyrosine phosphorylation in uences Fyn- SH2 binding to target proteins, we set out to deter-mine whether or not tau binds to Fyn -SH2. CHO ... disruption of the association of these proteins could represent a poten-tial therapeutic strategy for the treatment of AD. Here,we used GST fusion proteins of Fyn -SH2 and Fyn-SH3 to further investigate...