Tài liệu Báo cáo khoa học: The role of electrostatic interactions in the antitumor activity of dimeric RNases docx

Tài liệu Báo cáo khoa học: Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity pptx

... promoting an increase in proopiomelanocortin and cocaine and amphetamineregulated transcript. Taken together, these ﬁndingsprovide a compelling argument for the role for malo-nyl-CoA in regulating ... and certain amino acids [16].A linkage between fatty acid synthesis in the CNSand feeding behavior was uncovered with the ﬁndingthat systemic or intracerebroventricular administration of fatty ... entry of fatty acid into mitochon-dria. Thus, the steady-state level of malonyl-CoA in these tissues is determined by the relative activities of ACC and malonyl-CoA decarboxylase. Role of the...

Tài liệu Báo cáo khoa học: A genetic screen identifies mutations in the yeastWAR1 gene, linking transcription factor phosphorylation to weak-acid stress adaptation docx

... were raised in rabbitsagainst a GST-War1p fusion protein containing 294 aminoacids of the C-terminal part of War1p (amino acids 650–944) fused in- frame to the C-terminus of GST. The genefusion ... DNA-binding zinccluster at the N-terminus, whereas the acidic activationdomain is usually present at the C-terminus. The mid-dle homology region (MHR) bridging the DNA-bind-ing and the activation ... expression of the C-terminal 294 amino acids of WAR1 fused in- frameto the C-terminus of GST. Escherichia coli strain DH5aharboring pCG1950 was grown on 37 °CtoanA600 of 0.5.Expression of the GST-War1p...

Tài liệu Báo cáo khoa học: "A HYBRID APPROACH TO REPRESENTATION IN THE JANUS NATURAL LANGUAGE PROCESSOR" pot

... defining the set of items that have ever been the actor in a flight. Their definition is solely within NIKL using the QUA link [14], which is exactly the set of fillers of a slot. While having ... expressions in intensional logic. 3 4. Use of the Taxonomy in Janus By domain mode/we mean the set of axioms en- coded in NIKL regarding the constants. The domain model serves several purposes in ... all of the definitions of approximately 200 items from the base vocabulary using the defini. tJons of those vocabulary items themselves in the dictionary. In this attempt, we encountered the...

Tài liệu Báo cáo khoa học: "Subgrammars, Rule Classes and Control in the Rosetta Translation System" ppt

... meanings). 2. the meaning of the rules (rule meanings). In Montague Grammar these meanings are ex- pressed in intensional logic. In the Rosetta system the meanings of rules and basic expressions ... for the compositional and the analytical definition of a language. This is proved by the formal definitions in subsection 6.2. The third problem concerned the consequences of defining the ... Compositionalit¥ Principle." The meaning of an expression is a function of the meaning of its parts and the way in which they are syntactically combined. This principle was adopted...

Tài liệu Báo cáo khoa học: A role of miR-27 in the regulation of adipogenesis ppt

... obese mice In order to gain insights into the potential biologicallyrelevant role of miR-27 in the regulation of adipose tis-sue functions in vivo, we examined the expression of miR-27 in the genetically ... together, these results illustratea critical and speciﬁc role of miR-27 in the regulation of adipogenic differentiation.miR-27 prevents the induction of PPARc andC⁄EBPa In order to delineate ... differentially regulatedor play a role under obese conditions in vivo. In the current study, we investigated the role of miRNAs in adipogenic differentiation using the mouseembryonic ﬁbroblast-derived...

Tài liệu Báo cáo khoa học: A role for the intersubunit disulﬁdes of seminal RNase in the mechanism of its antitumor action docx

... thusblocking protein synthesis and leading cells to death. The current model proposed for the mechanism of antitumouraction of BS-RNase is based on the ability of the proteinto resist the neutralizing ... hypothesize that the cytotoxic activity of the latter monomers was due to the presence in these proteins of disulﬁde bonds, with their potentialchemical instability. It is well known that in the ... cannot ﬁt into the horseshoe cavity of the inhibitor, whereas a monomeric form of the enzymecan, and is fully inhibited by CRI. Indeed, monomeric RNases lacking cytotoxic activity, such as bovine...

Tài liệu Báo cáo khoa học: Key role of the loop connecting the two beta strands of mussel defensin in its antimicrobial activity docx

... obtained by other groupswho also point to the role of the connecting loop of the b-hairpin of defensins. A combination of mutationalanalysis [35] and structural analysis of the plant defensinRs-AFP1 ... moleculecomprising Ôresidues in the protruding domain consisting of the type VI b-turn and the ﬁrst part of b-strand 3Õ (i.e. the b-hairpin loop and part of the adjoining b-sheet) andÔresidues in the loop ... Role of the hairpin loop in mussel defensin activity (Eur. J. Biochem. 270) 2807 Activity is correlated with the isoelectric point of peptides The in uence of the overall positive charge of the...

Tài liệu Báo cáo khoa học: "From HOPE en I''''ESPERANCE On the Role of Computational Neurolinguistics in Cross-Language Studies " pptx

... disambiguated word meaning. It is the in interaction of the results of these asynchronous processes that the process of comprehension is defined. The processes are independent of the know- ledge ... affected. The study includes off-line picture naming which forces use of articles in all of the above contexts, as well as on-line production of these morphemes in an attempt to determine in which ... HOPE, the determination of the phonetic representation of a recognized word determines the breadth of active competition amon 9 meanings for subsequent time intervals of the process. Depending...

Tài liệu Báo cáo khoa học: How to remain nonfolded and pliable: the linkers in modular a-amylases as a case study ppt

... near the N- and C-termini of the linkers: this suggests thata mobile connection with both the catalytic domainand the binding module is required for the function of the nanomachine. Furthermore, ... covering the face of the aromatic ring [25].Alternatively, the ring may sterically disfavor extensivebending in this region, which could result in unwanted interactions between the linker and the ... structure, away from the water mole-cules in the solvent. During the process of folding, aswell as in its ﬁnal fold, the stability of the molecularediﬁce is further modulated by interactions betweengroups...

Tài liệu Báo cáo khoa học: Membrane targeting and pore formation by the type III secretion system translocon pdf

... Yer-sinia, the increased synthesis of LcrV triggered by the activation of the system leads to the titration of LcrG,which binds LcrV in a 1 : 1 complex. In turn, thisresults in a release of the ... by the sug-gestion that pH sensing by Salmonella involves modi-ﬁcations in the assembly of the translocon, whichaffect the pH gradient within the needle, sending sig-nals to the base of the ... employed for the structural study of the T3SS translocation porewithin the eukaryotic membrane. Given the impor-tance of T3SS in the infection and invasion processes of a number of bacteria, these...

Xem thêm