... degradation and repair inageing and oxidative stressB. FriguetLaboratoire de Biologie et Biochimie Cellulaire du Vieillissement,Universite´Denis Diderot – Paris 7, Paris, France.E-mail: bfriguet@paris7.jussieu.frCellular ... decreased elimination of oxidized protein. Since the proteasome is in charge of protein turn-over and removal of oxidized protein, its fate during ageing hasreceived special attention, and evidence ... bedue to either or both: (i) decreased proteasome expression and con-tent, (ii) inactivation upon modification of proteasome subunits and (iii) formation of inhibitory proteins. However oxidized pro-teins...