... the following regions: 31 60, 61 12 3, 12 8 13 0, 13 6 14 1, 15 0 15 9, 16 4 18 4, 19 9–2 30 and 23 3–2 44 of the Rep245protein, i.e. all regions except those with gaps ⁄ inser-tions. In the Rep245 model, all ... differs from that of the pRN1 prim–pol which contains the D 111 , E 113 and D1 71 motif. The presence of an aspartic residue inplace of the glutamic one is likely to have functionalimplications: a ... D1 01, D103 and D166 and the adjacent H138 are present in the active site. Moreover, the construction of a reasonable model for the Rep245prim–pol domain (as we designate it from now on) from the...