... less sensitive to the pres-ence of the anion. These residues also modulate the conformation of unfol-ded cytochrome c, influencing its spin state and the coordination to the prosthetic group.AbbreviationCT, ... candidate for ligand X (the other likely candidates, i.e. the lysines, are fully proto-nated at pH 2.2) [18]. The heterogeneous character of the A-state promp-ted us to investigate the effect of sulfate ... A-state even in the absence of sulfate. Therefore, the kinetic progresscurve of Fig. 9B is expected to refer: (a) for the fastphase, to the sulfate-induced destabilization of the HSacid-denatured...