Tài liệu Báo cáo khoa học: Pharmacologic chaperoning as a st

Tài liệu Báo cáo khoa học: Pharmacologic chaperoning as a strategy to treat Gaucher disease ppt

... administration increased Q279E a- galactosidase A residual activity in patient derived cells; thus, galactose was demonstrated to be ﬁrst active-site-directed pharmacologic chaperone for a lysosomal storage disease. ... MINIREVIEW Pharmacologic chaperoning as a strategy to treat Gaucher disease Zhanqian Yu, Anu R. Sawkar and Jeffery W. Kelly Department of Chemistry...

Ngày tải lên : 18/02/2014, 16:20

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Tài liệu Báo cáo khoa học: Control analysis as a tool to understand the formation of the las operon in Lactococcus lactis doc

... CP-pyk (5¢-ACGACTAGTGGATCCATNNNNNAGTTTATTCTT GACANNNNNNNNNNNNNNTGRTATAATNNNNAA GTAATAAAATATTCGGAGGAATTTTGAAATGAATA AACGTGTAAAAATCG-3¢)(N¼ A, T, G, C) and pyk- back (5¢-CTCTACATGCATTTCAACAATAGGGCCTG TC-3¢) for ampliﬁcation of pyk. The resulting ... (5¢-GG AAGGATCCTTGTGTTTTTCTCCTATAATG-3¢) and downstream to pyk using primer pyk3 (5¢-GGAAGGA TCCTTTGTCAATTAATGATCTTAAAAC-3¢) and pyk4 (5¢-CTAGTC...

Ngày tải lên : 19/02/2014, 17:20

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Tài liệu Báo cáo khoa học: Fermentative lifestyle in yeasts belonging to the Saccharomyces complex ppt

... new genera Lachancea, Nakaseomyces, Naumovia, Vanderw- altozyma and Zygotorulaspora. FEMS Yeast Res 4, 233–245. 29 Wolfe KH & Shields DC (1997) Molecular evidence for an ancient duplication ... kluyveri (Table 1) [36]. A similar situation was detec- ted in species belonging to the Hanseniaspora genus. Hanseniaspora vinae and Hanseniaspora occidentalis did in fact exhibit the ability...

Ngày tải lên : 19/02/2014, 02:20

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Tài liệu Báo cáo khoa học: Phage-display as a tool for quantifying protein stability determinants pptx

... stabilities. Remarkably, we have found that, at least in some circumstances, a quanti- tative correlation to biophysical data can be obtained from a statistical analysis of selected phage populations ... the association of the variable heavy chain (V H )with protein A was used as a surrogate for direct stability measurements. The V H domains in camelid heavy chain antibodies are m...

Ngày tải lên : 19/02/2014, 12:20

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Tài liệu Báo cáo khoa học: "Sentence generation as a planning problem" pptx

... to be false. Actions have a number of param- eters, as well as a precondition and effect, both of which are logical formulas. When a planner tries to apply an action, it will ﬁrst create an action ... communicative goals as ﬂaws that the plan must remedy. To this end, we add an atom cg(P ,a 1 , ,a n ) for each element P (a 1 , ,a n ) of the communicative goal to the in...

Ngày tải lên : 20/02/2014, 12:20

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Tài liệu Báo cáo khoa học: Infrared spectroscopy as a tool for discrimination between sensitive and multiresistant K562 cells doc

... The data were analysed with a window of ﬁve wavenumbers, assuming that adjacent wavenumbers are highly corr elated. A population o f 3 2 solutions was built at each generation, and e valuated. ... cells a d ecrease of the absorptions assigned to fatty a cids and phospholipids relative to their protein content. This qua ntitative change was accompanied by qualitative modiﬁcation,...

Ngày tải lên : 21/02/2014, 03:20

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Tài liệu Báo cáo khoa học: "Contrastive accent in a data-to-speech system" doc

... generation of contrastive accent and propose an alternative method that is feasible and computationally at- tractive in data -to- speech systems. 1 Motivation The placement of pitch accent plays ... should have a contrastive accent, because the two teams Ajax and PSV are obviously in each other's alternative set. In fact, though, there is no contrast and PSV should be normal...

Ngày tải lên : 22/02/2014, 03:20

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Tài liệu Báo cáo khoa học: Upregulation of the a-secretase ADAM10 – risk or reason for hope? docx

... members of the ADAM family have been shown to act as a- secretase [8,36,37]: ADAM9, ADAM10 and ADAM17 (TACE). Overexpression of ADAM9 has been reported to increase the basal and protein kinase C (PKC) ... mecha- nism: ADAM9 has been shown to proteolytically pro- cess ADAM10 [40–42]. By contrast to ADAM9, ADAM10 was found to have constitutive and regu- lated a- secretase activity...

Ngày tải lên : 16/02/2014, 09:20

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Tài liệu Báo cáo khoa học: Mixed lineage leukemia: a structure–function perspective of the MLL1 protein ppt

... Milne TA, Copeland TD, Levine SS, Lee JC, Hayes DN, Shanmugam KS, Bhattacharjee A, Biondi CA et al. (2004) Menin associates with a trithorax family histone methyltrans- ferase complex and with ... general transcriptional co-activators that contain histone and transcription factor acetylation activities [30]. In addi- tion, CBP contains a number of protein-binding domains that mediate tra...

Ngày tải lên : 16/02/2014, 14:20

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Tài liệu Báo cáo khoa học: Bacitracin is not a speciﬁc inhibitor of protein disulﬁde isomerase pptx

... rhodanese was also decreased by bacitracin. The decrease in the noncatalyzed rate (31%) was similar to that of the PDI-catalyzed reaction (a 32% decrease). These results Fig. 1. Bacitracin has minimal ... showing a greater effect (29% decrease in aggregation rate) than PDI (18% decrease in rate). When 1mm bacitracin was added to the PDI-catalyzed reaction the rate of aggregation of rho...

Ngày tải lên : 16/02/2014, 14:20

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