Tài liệu Báo cáo khoa học: Studies on structural and functional divergence among seven WhiB proteins of Mycobacterium tuberculosis H37Rv pdf

... FEBS 93 Studies on structural and functional divergence among seven WhiB proteins of Mycobacterium tuberculosis H37Rv Md. Suhail Alam, Saurabh K. Garg* and Pushpa AgrawalInstitute of Microbial ... conditions.Fig. S4. Effect of air oxidation on the stability of [2Fe–2S] cluster of various WhiB proteins. Fig. S5. Insulin disulfide reduction assay of apoWhiB5, WhiB6 and WhiB7 .Fig. S6. Comparison ... appearance of purified WhiB1 , WhiB2 , WhiB5 , WhiB6 and WhiB7 indicated the presence of an iron–sulfur cluster. To identify and confirm thepresence of the iron–sulfur cluster, the absorptionspectra of...

Tài liệu Báo cáo khoa học: Oxidized elaﬁn and trappin poorly inhibit the elastolytic activity of neutrophil elastase and proteinase 3 pdf

... oxidation device[17]. Figure 1 shows the effect of increasing concen-trations of native and oxidized elaﬁn and trappin on the activity of a constant concentration of NE and Fig. 1. Inhibition of ... assessed byadding a constant concentration of enzyme to increas-ing concentrations of elastin, stirring for 10 min,centrifugating the suspensions and measuring theconcentration of unbound enzyme ... the total concentration of elastin and [R]0.5is the concentration for which 50% of enzymeis bound. Non-linear regression analysis based on Eqn (2) gave [R]0.5values of 0.77 ± 0.12 and 1.12...

Tài liệu Báo cáo khoa học: X-ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoate docx

... inhibition by panto-ate and the alleviation of this inhibition by high con-centrations of ATP.DiscussionPSs from all known sources are dimeric, although thecontribution of this dimerization to ... thestructures of PSs from E. coli and M. tuberculosis. Structural analysesAnalysis of the sites of substrate binding from NMR data, and structural comparison of the E. coli, M. tuberculosis and A. ... all backbone u and wdihedral angles occupy allowed regions of the Rama-chandran map [32,33]. Comparison of the monomer of the substrate-free form of E. coli PS [13] with themonomers of nPS in...

Tài liệu Báo cáo khoa học: "Kernels on Linguistic Structures for Answer Extraction" doc

... VectorMachines along with kernel functions can ef-fectively represent syntax and semantics. Ourexperiments on question/answer classificationshow that the above models highly improve on bag -of- words on a ... design of a classifier that decides if an an-swer correctly responds to the target question. Wedesign a classifier based on SVMs and different ker-nels applied to several forms of question and ... sparseness.representations:(1) linear kernels on the bag -of- words (BOW) orbag -of- POS-tags (POS) features,(2) the String Kernel (SK) (Shawe-Taylor and Cris-tianini, 2004) on word sequences (WSK) and POS-tag...

Tài liệu Báo cáo khoa học: "Panel on Natural Language and Databases" pot

... some of the merits of continuing research on natural language within the confines of constructing an interface for ordinary databases. One advantage is that the speed of processing is not of ... language. How much these cross-linguistic concerns ought to affect the construction of a particular system is itself one of the questions deserving of atten- tion, but our experience to date suggests ... fruitful to expand the scope of a natural language interface, to permit some manipulation of a programming environment, allowing not only the retrieval of information describing the state of the system,...

Tài liệu Báo cáo khoa học: "Constraints on Non-Projective Dependency Parsing" doc

... satisﬁesSINGLE-H EAD and ACYCLICITY) has degree 1.The only non-projective arc in the graph is (5, 1) and G(5,1)contains three connected components,each of which consists of a single root node (2, 3 and 4). ... conditions are independent in thatnone of them is entailed by any (combination) of the others. However, the conditions SINGLE-HEAD and ACYCLICITY together with the basicwell-formedness conditions ... measured by the number of ac-tive pairs in relation to sentence length. A plot of this relationship for a subset of the conditions canbe found in Figure 2. For reasons of space, weonly display the...

Tài liệu Báo cáo Y học: Studies on the nonmevalonate pathway of terpene biosynthesis The role of 2C-methyl-D -erythritol 2,4-cyclodiphosphate in plants docx

... to a lack of ﬁdelity of the isomerase that inter-converts IPP and DMAPP. Participation of the isomerase is of crucial importance in the mevalonate pathway, in whichformation of IPP and DMAPP ... molar fraction of the IPP isotopomer ccan be calculated (Fig. 6).The signals of C-12 and the coincident signals of carbonatoms 4 and 8 showed one bond13C–13C coupling satellites of lower ... incorporation of radio-actvity into lipid-soluble material was again checked bysolvent extraction of reaction mixtures and the consumption of 2C-methyl-D-erythritol 2,4-cyclodiphosphate wasmonitored...

Tài liệu Báo cáo khoa học: "REMARKS ON PLURAL ANAPHORA" pptx

... prepositions and verbs trigger processes of sum formation (with-PPs and meet are out- standing examples of these types of con- structions.) In (1.c), Michael with Maria triggers the formation of ... terms only. Often, several complex RefOs can be constructed, but only one of them is the preferred referent for the plural anaphor in question. As a means of explanation for preferred and non-preferred ... sibilty of the atomic RefOs. Let us summarize the discussion so far: There are linguistic concepts -such as conjunctions, prepositions and lexical concepts- which trigger the construction of...

Tài liệu Báo cáo khoa học: Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity pptx

... sup-pression of food intake and adiposity. Conversely, the ectopic expression of malonyl-CoA decarboxylase in the hypothalamus is sufﬁcient to pro-mote feeding and adiposity. Based on these and other ... to function even in the face of high concen-trations of energy-rich blood ketones and fatty acids[39]. The oxidation of long-chain fatty acids for energyhas long been thought to play a minor ... acid oxidation could contrib-ute to body weight control. The roles of long-chainfatty acyl-CoAs and long-chain fatty acid oxidation,which are both affected by the loss or inhibition of FAS, have...

Tài liệu Báo cáo khoa học: An anthrax lethal factor mutant that is defective at causing pyroptosis retains proapoptotic activity pdf

... data are consistentwith the notion that induction of pyroptosis and apop-tosis by LF occurs through the cleavage of distinctsubstrates.Results and DiscussionWe screened a collection of LF mutants, ... after LeTxtreatment, but only if they have been activated by bac-terial components. One group has suggested that con-comitant activation of the cells and downregulation of the p38 mitogen-activated ... 3). Exposure of cells to PA and increasingconcentrations of wild-type LF for 1 h resulted indecreased phosphorylation of the three MAPKs.Interestingly, increasing the LF concentration from10)11m...

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