Tài liệu Báo cáo khoa học: Modeling of tRNA-assisted mechanism of Arg activation based on a structure of Arg-tRNA synthetase, tRNA, and an ATP analog (ANP) ppt
... JM, Dando PM, Rawlings ND, Brown MA,
Young NE, Stevens RA, Hewitt E, Watts C & Barrett
AJ (1997) Cloning, isolation, and characterization of
mammalian legumain, an asparaginyl endopeptidase.
J ... importance for
the effect of S10 0A4 on MMP and TIMP regulation
and thereby on the cell’s possibility to promote inva-
sion and metastasis.
Materials and methods
Materials
DM...
... “pure backoff”, or “pure
interpolation”. In pure backoff methods, all in-
stances of α = 1 and all instances of β = 0. The
pure backoff methods we consider are Katz back-
off and backoff absolute ... β, and γ parame-
ters depend on the context w
1
. w
n−1
. For each
context, the values of α, β, and γ must be set to
produce a normalized conditional probability dis-
tribution....
... activation
based on a structure of Arg- tRNA synthetase, tRNA, and
an ATP analog (ANP)
Michiko Konno
1
, Tomomi Sumida
1,
*, Emiko Uchikawa
1
, Yukie Mori
1
, Tatsuo Yanagisawa
2,
*,
Shun-ichi Sekine
2
and ... relative posi-
tions of Arg, A7 6 of tRNA
Arg
and ATP on ArgRS
was undertaken to find the suitable position for the
tRNA-assisted mechanis...
... predicate-
argument structures for statistical machine
translation: 1) a predicate translation model
and 2) an argument reordering model. The
predicate translation model explores lexical
and semantic ... its
predicate-argument structure and English transla-
tion. The verbal predicate “/adjourn” (in bold)
has 4 arguments: one in an ARG0 agent role, one
in an ARGM-ADV adverbi...
... feedback prediction in dyadic
conversations. Backchannel feedback includes the
nods and paraverbals such as ”uh-huh” and ”mm-
hmm” that listeners produce as they are speaking.
Backchannels play a ... an absolute gold standard.
Snow et. al. (2008) show that using non-expert la-
bels for training machine learning algorithms can be
as effective as using a gold standard annotation.
In t...
... Yonezawa M, Maruyama K, Yamaguchi-Shino-
zaki K & Shinozaki K (2007) The mitogen-activated
protein kinase cascade MKK3-MPK6 is an important
part of the jasmonate signal transduction pathway ... MPK3 and MPK6 kinase activity has been shown
to be activated by ROS [28], as well as by bacterial
and fungal elicitors [29,30]. Because oxi1 mutant plants
are impaired in the activation...
... Schematic diagram of soluble 1-15 and 1-15 R 2A mutant
Myc epitope-tagged receptors, co-immunoprecipitation and ligand
binding analysis of soluble 1-15 and 1-15R 2A mutant FLAG and
Myc epitope-tagged ... The data were graphed and analyzed using
graphpad prismÔ (Graphpad Software, San Diego, CA,
USA). Ligand binding parameters were measured by com-
petitive binding analysis. Eq...
... fungi and archaea). We compare 2,5-diamino-6-
ribitylamino-4(3H)-pyrimidinone 5¢-phosphate synthases from the yeast
Candida glabrata, the archaeaon Methanocaldococcus jannaschii and the
eubacterium ... (C), deaminase (D, G), reductase
(E, F), terminal enzymes of the pathway (H). The biosynthetic pathway proceeds via reactions D and E in eubacteria and plants and
via reactions F a...
... in one strand and two AG steps in the other. The
mdm2 target, whose interaction with p53 was most
strongly affected by DNA cis-platination, contains
GG, GGG and AG motifs in one strand and GG and
GTG ... double-stranded
DNA containing the major adduct of the anticancer
drug cisplatin. Nature 377, 649–652.
29 Zlatanova J, Yaneva J & Leuba SH (1998) Proteins that
specifically recog...
... and its derivatives
used in this study.
Name Sequence (residues 91–100)
WT GGGAGGGGGG
polyAla *SA*AAAAA*
AGG AAA*******
GAG ****AAA***
GGA *******AAA
GAA ****AAAAAA
AGA AAA****AAA
AAG AAA*AAA***
GGD ... supernatant and the membrane frac-
tions was similar to those of GGN, GGD, GGS, and
AAG (Figs 2B and 4B). Interestingly, similar to the
case of GGN mutant, a small but significant...