Tài liệu Báo cáo khoa học: Toggle switches, pulses and oscillations are intrinsic properties of the Src activation/deactivation cycle doc

Tài liệu Báo cáo khoa học: Toggle switches, pulses and oscillations are intrinsic properties of the Src activation/deactivation cycle doc

Tài liệu Báo cáo khoa học: Toggle switches, pulses and oscillations are intrinsic properties of the Src activation/deactivation cycle doc

... ª 2009 The Authors Journal compilation ª 2009 FEBS Toggle switches, pulses and oscillations are intrinsic properties of the Src activation/deactivation cycle Nikolai P. Kaimachnikov 1,2 and Boris ... branch of the Z-shaped curve (i.e. low Src activity) and the state O 3 at the upper branch (i.e. high Src activity) are both Switches, pulses an...
Ngày tải lên : 18/02/2014, 11:20
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Tài liệu Báo cáo khóa học: Active-site residues and amino acid specificity of the bacterial 4¢-phosphopantothenoylcysteine synthetase CoaB pptx

Tài liệu Báo cáo khóa học: Active-site residues and amino acid specificity of the bacterial 4¢-phosphopantothenoylcysteine synthetase CoaB pptx

... has Fig. 5. Analysis of the enzymatic activity of His-CoaB R206Q and A276V. The synthesis of 4¢-phosphopantothenoyl-CMP (–cysteine, upper part of the figure) and of 4¢-phosphopantothenoylcysteine (+ ... Asn210 and Ala276 are important for the second-half reaction and are part of the active-site of CoaB; these residues may be directly involved in binding of...
Ngày tải lên : 19/02/2014, 12:20
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Tài liệu Báo cáo Y học: Electrochemical, FT-IR and UV/VIS spectroscopic properties of the caa3 oxidase from T. thermophilus docx

Tài liệu Báo cáo Y học: Electrochemical, FT-IR and UV/VIS spectroscopic properties of the caa3 oxidase from T. thermophilus docx

... we study the electrochemical, UV-VIS and FT-IR spectroscopic properties of the caa 3 - oxidase from T. thermophilus in the presence and absence of cyanide, and compare the observed properties ... with the oxidized and the negative signals with the reduced form of the enzyme. For the reduced form, the Soret band can be observed at 415 and 442 nm, and f...
Ngày tải lên : 21/02/2014, 15:20
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Tài liệu Báo cáo khoa học: Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2? docx

Tài liệu Báo cáo khoa học: Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2? docx

... evidence for an interaction between the two domains is the ability of numerous substrates and modulators of ABCG2 (and the R482G isoform) to stimulate the rate of ATP hydrolysis [21,24,25], albeit ... concentration of 0.6 m M. The amount of [ 3 H]daunomycin bound to the membranes in the absence of nucleo- tide was assigned a value of unity, and all other data...
Ngày tải lên : 18/02/2014, 18:20
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Tài liệu Báo cáo khoa học: Multiple promoters regulate tissue-specific alternative splicing of the human kallikrein gene, KLK11⁄hippostasin ppt

Tài liệu Báo cáo khoa học: Multiple promoters regulate tissue-specific alternative splicing of the human kallikrein gene, KLK11⁄hippostasin ppt

... isoforms 1 and 2 are detected in the organ. All of these nucleotide sequences were identical to the genomic sequence of the human KLK11 gene (GenBank accession number AF164623). We compared the ... the regulation and characteristics of these isoforms are unknown. We identified the first three exons (1a, 1b, and 1c) by determining their transcription initiation sites....
Ngày tải lên : 19/02/2014, 06:20
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Tài liệu Báo cáo khoa học: "Exploiting Readymades in Linguistic Creativity: A System Demonstration of the Jigsaw Bard" docx

Tài liệu Báo cáo khoa học: "Exploiting Readymades in Linguistic Creativity: A System Demonstration of the Jigsaw Bard" docx

... instances of the patterns “as ADJ and * as” and “as * and ADJ as” from Google, noting the combinations that are found and their frequencies. These frequencies provide link weights for the Hofstadter-style ... the scale of the Bard’s genera- tivity, and the quality of its insights. 5 Empirical Evaluation The vastness of the web, captured in the large- scal...
Ngày tải lên : 20/02/2014, 05:20
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Tài liệu Báo cáo khoa học: Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity pptx

Tài liệu Báo cáo khoa học: Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity pptx

... diverse population of cells. The role of malonyl-CoA and other intermediary metabolites is an exciting area of research and poten- tially a therapeutic avenue to treat obese and diabetic people. ... entry of fatty acid into mitochon- dria. Thus, the steady-state level of malonyl-CoA in these tissues is determined by the relative activities of ACC and malonyl-CoA deca...
Ngày tải lên : 14/02/2014, 22:20
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Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR-targeted anticancer therapy doc

Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR-targeted anticancer therapy doc

... genotype-directed therapy in this disease. KRAS mutation as a mechanism of resistance to EGFR-targeted therapy The KRAS protein is localized to the inner surface of the cell membrane. The binding of ligand ... reposition- ing of critical residues surrounding the ATP-binding cleft of the tyrosine kinase domain of the receptor and thereby stabilize the interaction...
Ngày tải lên : 16/02/2014, 09:20
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Tài liệu Báo cáo khoa học: Accessibility changes within diphtheria toxin T domain when in the functional molten globule state, as determined using hydrogen⁄deuterium exchange measurements pdf

Tài liệu Báo cáo khoa học: Accessibility changes within diphtheria toxin T domain when in the functional molten globule state, as determined using hydrogen⁄deuterium exchange measurements pdf

... define the core of the protein’s N state [21]. For the T domain, these were the center of TH5 and TH8, and the N-terminal half of TH9. All a-helices (TH1, 3, 4, 5’, 6, 7 and the remaining parts of TH5 ... in the N state and the evolution of the overall structure of the protein in the MG state. This degree of resolution is unprecedented for the T do...
Ngày tải lên : 16/02/2014, 09:20
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Tài liệu Báo cáo khoa học: X-ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoate docx

Tài liệu Báo cáo khoa học: X-ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoate docx

... respectively, whereas the similar atoms of Gln155 are hydrogen- bonded to the O2 and O3 atoms of pantoate, respec- tively. These two residues are conserved in the E. coli and M. tuberculosis proteins, and are ... between the O2 atom of pantoate and the Nf atom of the side chain of Lys39. However, there are a large number of water-mediated networked inte...
Ngày tải lên : 16/02/2014, 09:20
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