... ª 2009 The Authors Journal compilation ª 2009 FEBS
Toggle switches, pulses and oscillations are intrinsic
properties of the Src activation/deactivation cycle
Nikolai P. Kaimachnikov
1,2
and Boris ... branch of
the Z-shaped curve (i.e. low Src activity) and the state
O
3
at the upper branch (i.e. high Src activity) are both
Switches, pulses an...
... has
Fig. 5. Analysis of the enzymatic activity of His-CoaB R206Q and A276V. The synthesis of 4¢-phosphopantothenoyl-CMP (–cysteine, upper part of
the figure) and of 4¢-phosphopantothenoylcysteine (+ ... Asn210 and Ala276
are important for the second-half reaction and are part of
the active-site of CoaB; these residues may be directly
involved in binding of...
... we study the electrochemical,
UV-VIS and FT-IR spectroscopic properties of the caa
3
-
oxidase from T. thermophilus in the presence and absence of
cyanide, and compare the observed properties ... with the oxidized and the negative
signals with the reduced form of the enzyme. For the
reduced form, the Soret band can be observed at 415 and
442 nm, and f...
... evidence for an interaction between
the two domains is the ability of numerous substrates
and modulators of ABCG2 (and the R482G isoform)
to stimulate the rate of ATP hydrolysis [21,24,25],
albeit ... concentration of 0.6 m
M. The amount of
[
3
H]daunomycin bound to the membranes in the absence of nucleo-
tide was assigned a value of unity, and all other data...
... isoforms 1 and 2 are
detected in the organ. All of these nucleotide sequences
were identical to the genomic sequence of the human
KLK11 gene (GenBank accession number AF164623).
We compared the ... the regulation and characteristics of
these isoforms are unknown. We identified the first three exons (1a, 1b,
and 1c) by determining their transcription initiation sites....
... instances of the patterns
“as ADJ and * as” and “as * and ADJ as” from
Google, noting the combinations that are found and
their frequencies. These frequencies provide link
weights for the Hofstadter-style ... the scale of the Bard’s genera-
tivity, and the quality of its insights.
5 Empirical Evaluation
The vastness of the web, captured in the large-
scal...
... diverse population of cells.
The role of malonyl-CoA and other intermediary
metabolites is an exciting area of research and poten-
tially a therapeutic avenue to treat obese and diabetic
people. ... entry of fatty acid into mitochon-
dria. Thus, the steady-state level of malonyl-CoA in
these tissues is determined by the relative activities of
ACC and malonyl-CoA deca...
... genotype-directed
therapy in this disease.
KRAS mutation as a mechanism of
resistance to EGFR-targeted therapy
The KRAS protein is localized to the inner surface of
the cell membrane. The binding of ligand ... reposition-
ing of critical residues surrounding the
ATP-binding cleft of the tyrosine kinase
domain of the receptor and thereby stabilize
the interaction...
... define the core of the protein’s N
state [21]. For the T domain, these were the center of
TH5 and TH8, and the N-terminal half of TH9. All
a-helices (TH1, 3, 4, 5’, 6, 7 and the remaining parts of
TH5 ... in the N state and the evolution of the overall
structure of the protein in the MG state. This degree
of resolution is unprecedented for the T do...
... respectively,
whereas the similar atoms of Gln155 are hydrogen-
bonded to the O2 and O3 atoms of pantoate, respec-
tively. These two residues are conserved in the E. coli
and M. tuberculosis proteins, and are ... between
the O2 atom of pantoate and the Nf atom of the side
chain of Lys39. However, there are a large number of
water-mediated networked inte...