... nucleosomes in the mainpeak, indicates that crosslinking is almost complete in the middle of the fibre, but some of the end-nucleo-somes are not crosslinked to the rest and thereforemust originate ... chromatin in which the presence of linker his-tone is questionable. Furthermore, the presence of alloligomers, with dimers up to the half the size of the original samples after digestion of the linkers, ... of thismaterial with trypsin initially caused a gradualdecrease of the number of nucleosomes per chain in the main peak, with a corresponding increase in the Fig. 5. UV absorbance profiles of...