... domain–domain interactions.AbbreviationsAD, Alzheimer’s disease; DTNB, 5,5¢-dithiobis-(1-nitrobenzoic acid); GIF, neuronal growth- inhibitory factor; hGIF, human neuronal growth- inhibitory factor; ... a-domain is not directlyinvolved in neuronal growth- inhibitory activity[5,6,17,18]. However, it has been well documented thatthe two domains of MT do not work independently,and domain–domain interactions ... GIF remains elusive. It has been reported that theneuronal growth- inhibitory activity of GIF is mainlyassociated with its b-domain, and the single a-domaindoes not show any growth- inhibitory...