... the linker B kinase region of SYK. The PH domain of TFKs usually binds to phosphatidylino-sitol-3,4,5-trisphosphate, thereby bringing them in close proximity to other membrane-tethered signalingproteins. ... Epstein–Barr virus infec-tion. Both kinases represent interesting targets for inhibition: in the case of BTK, as an immunosuppressant, whereas there is evidence that the inhibi-tion of inducible ... pro-tein kinase B (PKB)]. In AKT, a cysteine substitution of the corresponding R25 in the pleckstrin homology(PH) domain also results in loss of function [16,17],thereby demonstrating related...