... amongtissues in the body, and the risk of edema to brainfunctions should be carefully considered. Brain edemamay increase pressure in the cranial cavity and braintissue, resulting in suppression of ... VEGF-D, binds and activates thisreceptor, resulting in the proliferation and migration of lymph ECs and lymphangiogenesis [13].Angiogenesis in brain diseasesBrain strokeStroke is induced through: ... in the human genome. In addi-tion, VEGF-E encoded in the Orf virus binds and activates only VEGFR-2. Anti-(VEGF-A)IgG and aptamer, as well as VEGFR tyrosinekinase inhibitors (multikinase inhibitors)...