... sensitized them to
the toxicity of extracellular dopamine. Neuronal expression of p25a thus
holds the potential to sensitize the cells toward dopamine and toxins
carried by the dopamine transporter.
Structured ... compilation ª 2010 FEBS 505
P25a
⁄
TPPP expression increases plasma membrane
presentation of the dopamine transporter and...
... from the Win motif of MLL1
bound to the WD40 repeat protein, WDR5 [24,25] and
the C-terminal SET domain in the presence and
absence of histone peptides and the cofactor product,
S-adenosyl-homocysteine ... (green) bound to the central opening of WDR5 (PDB code
3EG6). The position of the conserved Arg 3765 is indicated. On the left, a stick representation is...
... neurodegenerative disease.
Synthesis and secretion of GIF in the
brain
Cellular and temporal localization of GIF
synthesis
Whilst the MT1 and MT2 isoforms are ubiquitously
synthesized throughout most ... Cu(II) and Zn(II), only the Cu(II)-
induced aggregation of Ab is toxic. The neurotoxicity of
Cu(II)-induced Ab aggregation is related to the genera-
tion of RO...
... simplify the protocol and shorten
the time needed to obtain a fully active ONC compared with
other procedures described in the literature. The application
of MALDI-TOF MS to the characterization of ... dehydration, together with acidification
and dilution of the samples, stopped the reactions. This
finding allowed the acquisition of spectra in the automatic
mod...
... we focus on
the roles of ANGPTL2 and ANGPTL6 ⁄ AGF in obes-
ity and related metabolic diseases, and discuss whether
these ANGPTLs could be targets for the prevention
and treatment of these conditions.
Suppression ... ⁄ AGF null mice, and increases in the expression
of PPARa, PPARd and PGC-1a in skeletal muscle of
ANGPTL6 ⁄ AGF transgenic mice [14]. Mo...
... incubated with
the reactivase in the presence of ADP and Mg
2+
and
followed by nondenaturing PAGE, the bands of the
enzyme and the reactivase were markedly reduced
in density, and two bands of the enzymeÆreactivase
complexes ... Positions of DD and its subun-
its (a
D
, b
D
and c
D
) and the reactivase (DD-R) and its subunits (a
R
and b
R
) are indicate...
... the control of doxycyclin [22,23].
Expression of either EGFR mutant led to the develop-
ment of adenocarcinomas similar to human BACs, and
the withdrawal of doxycycline to reduce expression of
the ... regula-
tory domain. These provide docking sites for downstream molecules and
lead to the evasion of apoptosis, to proliferation, to invasion and to...
... BiP,
PDI and DsbC.
To further study the mechanism of action of bacitra-
cin, the reduction of insulin was analyzed in the pres-
ence of the PDI a domain and DsbA, which are
capable of catalyzing the ... Triton
X-100 and 2-propylphenol [3,38]. To study the effect
of inhibitors of substrate binding on the reductive
activity of PDI, the precipitation of...
... synthesis; accelerator actuator: comprises the
control and synthesis of the PTS mRNA; brake actua-
tor: describes the control and synthesis of the PtsG
repressor Mlc. Protein synthesis is described ... popular [21]. One advantage of the
method of modular modeling is that the granularity of
the submodels can easily be adjusted to the objective
of the model...
... obtained
using NotI as the landmark enzyme and HinfI as the second dimension fragmentation enzyme. Although most of the spots are located on
the top left (short in the first dimension and long in the second ... mixture
[100 ng each of landmark- and HinfI-adapter and 5 lLof
Ligation High solution (Toyobo, Tokyo, Japan) in 8.5 lL].
The mixture was incubated at 16 °C for...