... connectivity, CysI-CysIII and CysII-
CysIV. The disulfide bonds are shown in blue. (C) A three-dimensional
structure of the ribbon disulfide bond isomer of AuIB, where the
connectivities are CysI-CysIV ... provided insight
into approaches aimed at improving the bioavailability of
conotoxins. In particular, two lipophilic analogues of the
conotoxin MII were recently developed [53], b...
... Approach
Arabic words are often ambiguous in their morpho-
logical analysis. This is due to Arabic’s rich system
of affixation and clitics and the omission of disam-
biguating short vowels and other ... no-
tion of ambiguity class in the feature classifiers; in-
stead we investigate different ways of using the re-
sults of the individual feature classifiers in directly
choosing a...
... cultures (Fig. 1), indicating that the ini-
tial hydrolysis of haemoglobin is not inhibited by MA.
In addition, the morphology of infected erythrocytes
incubated in the presence of MA is visibly different
from ... insulysin and pitrilysin [32], possibly involved in the
processing of apicoplast protein leader sequence.
Inhibition of any of these activities could contribute to
MA...
... closely linked binding sites within a
discrete region. A corollary of this concept is that
binding sites for transcription factors are not normally
Active chromatin and DNase I hypersensitive sites ... premature ini-
tiation of transcription elongation [137].
The initiation and elongating phases of the tran-
scription cycle are characterized by distinct sets of his...
... (1989)
Kinetic characterization of the recombinant ribonucle-
ase from Bacillus amyloliquefaciens (barnase) and inves-
tigation of key residues in catalysis by site-directed
mutagenesis. Biochemistry ... docking
of mononucleotides, dinucleotides and trinucleotides
into the active site of RNase Sa2 contributed to a better
understanding of enzyme–substrate recognition.
Results
D...
... formation of quinonoid intermediate by
the addition of 10 mm glycine and varying FTHF con-
centrations. As shown in Fig. 6 the double reciprocal
plot for the formation of quinonoid intermediate ... on the formation
of a quinonoid intermediate and gem-diamine complex
and a slow dissociation of FTHF also indicate that
E53QbsSHMT exhibits enzyme memory. This is the
first instance...
... prosegment is present in all APs and is involved
either in the inactivation or in the correct folding, stability
and intracellular sorting of several zymogens [16], the PSI is
an insertion only identified ... likely because
their enzymatic properties are atypical and their localiza-
tions are unexpected.
New questions concerning functional significance and
specialization of this mul...
... lipid mixing as de fined in Experimental
procedures is plotted against peptide to lipid ratio i ndicates
that the peptide is capable of promoting lipid mixing of
vesicles consisting of DMPC and ... Additionally, a
peptide d erived from randomized sequence of IFP–wt (see
Supplementary data) exhibited insignifi cant lipid mixing
activity, demonstrating the specificity of the activity...
... linked to N9 of adenine is
called the ‘southern’ ribose; Fig. 1) and the N1 of the
adenine ring [4].
Besides d-myo-inositol 1,4,5-trisphosphate (InsP
3
)
and nicotinic acid adenine dinucleotide phosphate
(NAADP; ... MINIREVIEW
Second messenger function and the structure activity
relationship of cyclic adenosine diphosphoribose (cADPR)
Andreas H. Guse
University Medical Center H...
... reported for a similar size of train-
ing data. At the time of this paper, we did not
have the time to investigate if it is a problem of
non-optimal settings in GIZA++, or if the train-
ing data we ... arise often
(and are often intractable) in the use of a proba-
bilistic model: “what are the marginal probabili-
ties of each individual variable?” and “what is the
set of value...