... longer incubationperiods. Interestingly, the interruption of TAG synthe-sis preceded the appearance of toxic effects, supporting the notion that it constitutes the initiating event in the process ... Exposure of a variety of celltypes, including hepatocytes, to long-chain saturatedfatty acids (SFAs) led to increased expression of proin-flammatory cytokines, inhibition of insulin signaling,induction ... (Fig. 5B). The ER is the site of synthesis of all secretory pro-teins and resident proteins of the membrane system, and any perturbation that compromises the protein-folding capacity of the organelle...